ChemicalBook > CAS DataBase List > SB 203580 (hydrochloride)

SB 203580 (hydrochloride)

Product Name: SB 203580 (hydrochloride)
CAS No.: 869185-85-3
Chemical Name: SB 203580 (hydrochloride)
Synonyms: SB203580 HCl;RWJ 64809 HCl;RWJ 64809 hydrochloride;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride;SB 203580 hydrochloride, p38 MAPK inhibitor;SB 203580 hydrochloride (RWJ 64809 hydrochloride;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE
CBNumber: CB52592405
Molecular Formula: C21H17ClFN3OS
Formula Weight: 413.9
MOL File: 869185-85-3.mol

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SB 203580 (hydrochloride) Property

storage temp.: -20C
solubility: insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO
form: Bright yellow solid
color: Light yellow to yellow
Water Solubility: Soluble to 25 mM in water
Stability:: Hygroscopic

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 559395
Product name: SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem<br />SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC = 34 nM in vitro, 600 nM in cells).
Packaging: 1mg
Price: $177
Updated: 2025/07/31

Sigma-Aldrich

Product number: 559395
Product name: SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem<br />SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC = 34 nM in vitro, 600 nM in cells).
Packaging: 10mg
Price: $370
Updated: 2025/07/31

Cayman Chemical

Product number: 13344
Product name: SB 203580 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 13344
Product name: SB 203580 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $210
Updated: 2024/03/01

Cayman Chemical

Product number: 13344
Product name: SB 203580 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $493
Updated: 2024/03/01

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SB 203580 (hydrochloride) Chemical Properties,Usage,Production

Uses

SB 203580 Hydrochloride is a protein kinase inhibitor.

General Description

A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).

Biological Activity

sb203580 hcl is a specific inhibitor of p38-mapks with ic50 value of 0.6 μm [1].sb203580 is an inhibitor of p38-mapkα and p38-mapkβ. in neonatal myocytes, sb203580 prevented p38-mapk from activating mapkapk2 with ic50 value of 70 nm. it also significantly suppressed mapkapk2 activation in by il-1, osmotic stress or arsenite in kb cells. in neonatal rat ventricular myocytes, sb203580 inhibited jnk activity of activating c-jun with ic50 value of 3-10 μm. besides that, sb203580 affected the phosphorylation of small heat shock proteins caused by mapkapk2. it inhibited the il-1-, chemical- or osmotic stress-stimulated hsp27 phosphorylation with ic50 value of < 1μm in kb cells [1, 2].

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

References

[1] cuenda a, rouse j, doza y n, et al. sb 203580 is a specific inhibitor of a map kinase homologue which is stimulated by cellular stresses and interleukin-1. febs letters, 1995, 364(2): 229-233.
[2] clerk a, sugden p h. the p38-mapk inhibitor, sb203580, inhibits cardiac stress-activated protein kinases/c-jun n-terminal kinases (sapks/jnks). febs letters, 1998, 426(1): 93-96.

SB 203580 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 203580 (hydrochloride) Suppliers

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869185-85-3, SB 203580 (hydrochloride)Related Search:

SB 203580

RWJ 64809 hydrochloride

RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE

SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem

Adezmapimod (hydrochloride)

Adezmapimod (SB-203580) hydrochloride

RWJ 64809 HCl

SB203580 HCl

SB 203580 hydrochloride, p38 MAPK inhibitor

SB 203580 hydrochloride (RWJ 64809 hydrochloride

869185-85-3

C21H17ClFN3OS