URB937

Product Name: URB937
CAS No.: 1357160-72-5
Chemical Name: URB937
Synonyms: URB937;URB937, 10 mM in DMSO;3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate;3'-Carbamoyl-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate;3'-Carbamoyl-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate;Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester;Carbamic acid, N-cyclohexyl-, 3'-(aminocarbonyl)-6-hydroxy[1,1'-biphenyl]-3-yl ester;FAAH,URB 937,Inhibitor,URB937,low,toxicity,inhibit,Fatty acid amide hydrolase,OEA,URB-937
CBNumber: CB52592814
Molecular Formula: C20H22N2O4
Formula Weight: 354.4
MOL File: 1357160-72-5.mol

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URB937 Property

Boiling point:: 562.8±50.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble15mg/mL, clear
pka: 9.08±0.50(Predicted)
form: powder (1:1 ratio of product to ethanol)
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0448
Product name: URB937
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $38.12
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0448
Product name: URB937
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $370
Updated: 2024/03/01

Cayman Chemical

Product number: 10674
Product name: URB937
Purity: ≥95%
Packaging: 5mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 10674
Product name: URB937
Purity: ≥95%
Packaging: 10mg
Price: $76
Updated: 2024/03/01

Cayman Chemical

Product number: 10674
Product name: URB937
Purity: ≥95%
Packaging: 50mg
Price: $312
Updated: 2024/03/01

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URB937 Chemical Properties,Usage,Production

Uses

URB 937 is a potent inhibitor of fatty-acid amide hydrolase (FAAH), an intracellular serine hydrolase responsible for the deactivation of the endocannabinoid anandamide. It is actively extruded from the central nervous system (CNS), and therefore increases anandamide levels exclusively in peripheral tissues.

Biological Activity

URB937 is a fatty acid amide hydrolase (FAAH) inhibitor th at is actively excluded from the CNS by the membrane transporter ABCG2. The ED50 for inhibition of FAAH activity in the brain is 200 times higher than inhibition of renal FAAH activity. In vivo administration of URB937 elevates anandamide levels in peripheral tissues, and attenuates acetic acid-induced writhing, hyperalgesia in a sciatic nerve ligation model, and pain and edema in carrageenan injected paws.

URB937 Preparation Products And Raw materials

Raw materials

Preparation Products

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URB937 Suppliers

Canada 1 China 58 India 1 United States 10 Global 70

J & K SCIENTIFIC LTD.

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1357160-72-5, URB937Related Search:

URB597

URB937

Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester

3'-Carbamoyl-6-hydroxybiphenyl-3-yl cyclohexylcarbamate

Carbamic acid, N-cyclohexyl-, 3'-(aminocarbonyl)-6-hydroxy[1,1'-biphenyl]-3-yl ester

3'-Carbamoyl-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate

FAAH,URB 937,Inhibitor,URB937,low,toxicity,inhibit,Fatty acid amide hydrolase,OEA,URB-937

3'-Carbamoyl-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate

URB937, 10 mM in DMSO

1357160-72-5