1-(3-nitrophenyl)-1H-pyrazole
- Product Name
- 1-(3-nitrophenyl)-1H-pyrazole
- CAS No.
- 25688-18-0
- Chemical Name
- 1-(3-nitrophenyl)-1H-pyrazole
- Synonyms
- 1-(3-nitrophenyl)-1H-pyrazole;1H-Pyrazole, 1-(3-nitrophenyl)-
- CBNumber
- CB52593806
- Molecular Formula
- C9H7N3O2
- Formula Weight
- 189.17
- MOL File
- 25688-18-0.mol
1-(3-nitrophenyl)-1H-pyrazole Property
- Melting point:
- 94.5-95 °C
- Boiling point:
- 323.6±25.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.60±0.12(Predicted)
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N498025
- Product name
- 1-(3-Nitrophenyl)-1H-pyrazole
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- N498025
- Product name
- 1-(3-Nitrophenyl)-1H-pyrazole
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR932686
- Product name
- 1-(3-Nitrophenyl)-1H-pyrazole
- Purity
- 95%
- Packaging
- 250mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- OR932686
- Product name
- 1-(3-Nitrophenyl)-1H-pyrazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $435
- Updated
- 2021/12/16
- Product number
- CM187996
- Product name
- 1-(3-nitrophenyl)-1H-pyrazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $174
- Updated
- 2021/12/16
1-(3-nitrophenyl)-1H-pyrazole Chemical Properties,Usage,Production
Synthesis
288-13-1
645-00-1
25688-18-0
In a 50 mL round bottom flask, 1-iodo-3-nitrobenzene (1.0 mmol), pyrazole (1.2 mmol), ligand (0.04 mmol), cuprous oxide (0.10 mmol), cesium carbonate (2.0 mmol), and dry solvent (20 mL) were added sequentially. The reaction system was placed under nitrogen protection. The reaction mixture was heated to the indicated temperature in an oil bath under continuous stirring and cooled to room temperature after 20 h of reaction. The reaction mixture was filtered through a porous filter funnel filled with diatomaceous earth and the filter cake was washed with ethyl acetate. If DMSO is used as solvent, the filtrate is washed three times with 25 mL of water for extraction. The organic phases were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to give the crude product. Finally, the crude product was purified by silica gel column chromatography, and the eluent was a solvent mixture of hexane and ethyl acetate in a volume ratio of 3:1.
References
[1] Journal of Organic Chemistry, 2007, vol. 72, # 23, p. 8969 - 8971
[2] Tetrahedron Letters, 2016, vol. 57, # 20, p. 2197 - 2200
[3] Angewandte Chemie, International Edition, 2009, vol. 48, # 40, p. 7398 - 7401
[4] Angewandte Chemie, 2009, vol. 121, # 40, p. 7534 - 7537
[5] Tetrahedron Letters, 2011, vol. 52, # 52, p. 7171 - 7174
1-(3-nitrophenyl)-1H-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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