1H-Indazole-5-carboxylicacid,3-forMyl-
- Product Name
- 1H-Indazole-5-carboxylicacid,3-forMyl-
- CAS No.
- 885519-98-2
- Chemical Name
- 1H-Indazole-5-carboxylicacid,3-forMyl-
- Synonyms
- 3-ForMyl-1H-indazole-5-carboxylic;3-Formyl-5-indazole carbocylic acid;3-formyl-2H-indazole-5-carboxylic acid;1H-Indazole-5-carboxylicacid,3-forMyl-
- CBNumber
- CB52594656
- Molecular Formula
- C9H6N2O3
- Formula Weight
- 190.16
- MOL File
- 885519-98-2.mol
1H-Indazole-5-carboxylicacid,3-forMyl- Property
- Boiling point:
- 521.9±30.0 °C(Predicted)
- Density
- 1.594±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.76±0.30(Predicted)
- Appearance
- Brown to reddish brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- F449605
- Product name
- 3-Formyl-1H-indazole-5-carboxylicAcid
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CHM0078799
- Product name
- 3-FORMYL-1H-INDAZOLE-5-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $633.06
- Updated
- 2021/12/16
- Product number
- 4338AC
- Product name
- 3-Formyl-1H-indazole-5-carboxylicacid
- Packaging
- 1g
- Price
- $809
- Updated
- 2021/12/16
- Product number
- CHM0078799
- Product name
- 3-FORMYL-1H-INDAZOLE-5-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $916.84
- Updated
- 2021/12/16
- Product number
- CM132881
- Product name
- 3-formyl-1H-indazole-5-carboxylicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $316
- Updated
- 2021/12/16
1H-Indazole-5-carboxylicacid,3-forMyl- Chemical Properties,Usage,Production
Uses
3-Formyl-1H-indazole-5-carboxylic Acid was prepared by nitrosation of indoles. Indazole derivatives are useful as kinase inhibitors.
Synthesis
1670-81-1
885519-98-2
The general procedure for the synthesis of 3-formyl-5-carboxyindazole from indole-5-carboxylic acid was as follows: i) Preparation of 3-formyl-1H-indazole-5-carboxylic acid: indole-5-carboxylic acid (5.5 g, 0.0338 mol) was dissolved in water (250 ml), followed by the addition of sodium nitrite (NaNO2, 23.5 g, 0.338 mol) and a hydrochloric acid solution (6 N 42 ml, 0.293 mol). The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the precipitate was collected by filtration, washed with water (270 ml) and dried at 50 °C to afford 3-formyl-1H-indazole-5-carboxylic acid (5.36 g, 0.028 mol, 83% yield), which could be used in the subsequent steps without further purification.
References
[1] Patent: US2006/142247, 2006, A1. Location in patent: Page/Page column 39
[2] RSC Advances, 2018, vol. 8, # 24, p. 13121 - 13128
[3] Patent: WO2007/107346, 2007, A1. Location in patent: Page/Page column 35
1H-Indazole-5-carboxylicacid,3-forMyl- Preparation Products And Raw materials
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