1-Methyl-1H-1,2,3-triazole-5-carbaldehyde
- Product Name
- 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde
- CAS No.
- 202931-88-2
- Chemical Name
- 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde
- Synonyms
- 3-methyltriazole-4-carbaldehyde;1-Methyl-1H-1,2,3-triazole-5-carbaldehyde;3-Methyl-3H-[1,2,3]triazole-4-carbaldehyde;1H-1,2,3-Triazole-5-carboxaldehyde, 1-methyl-
- CBNumber
- CB52595875
- Molecular Formula
- C4H5N3O
- Formula Weight
- 111.1
- MOL File
- 202931-88-2.mol
1-Methyl-1H-1,2,3-triazole-5-carbaldehyde Property
- Boiling point:
- 253.5±32.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.22±0.10(Predicted)
- Appearance
- Colorless to off-white Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M327868
- Product name
- 1-methyl-1H-1,2,3-triazole-5-carbaldehyde
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 7878BB
- Product name
- 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde
- Packaging
- 250mg
- Price
- $309
- Updated
- 2021/12/16
- Product number
- CHM0387211
- Product name
- 1-METHYL-1H-1,2,3-TRIAZOLE-5-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.95
- Updated
- 2021/12/16
- Product number
- 7878BB
- Product name
- 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde
- Packaging
- 1g
- Price
- $699
- Updated
- 2021/12/16
- Product number
- A337228
- Product name
- 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $143
- Updated
- 2021/12/16
1-Methyl-1H-1,2,3-triazole-5-carbaldehyde Chemical Properties,Usage,Production
Synthesis
16681-65-5
68-12-2
202931-88-2
1.6 M n-butyllithium (0.9 mL, 1.4 mmol) was added slowly and dropwise to a tetrahydrofuran (THF, 10 mL) solution of 1-methyl-1H-1,2,3-triazole (32.0 mg, 1.2 mmol) at -78 °C, ensuring that the reaction temperature was maintained below -60 °C. After the reaction mixture was stirred continuously at -78 °C for 30 min, N,N-dimethylformamide (0.14 mL, 1.8 mmol) was added. Subsequently, the reaction system was slowly warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate (3 × 10 mL). The organic phases were combined, washed with water (3 x 10 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with an eluent ratio of 95:5 to 100:0 dichloromethane to methanol, resulting in 1-methyl-1H-1,2,3-triazole-5-carboxaldehyde as a yellow oil (40 mg, 30% yield).1H NMR (CDCl3) data: δ 4.10 (s, 3H), 7.88 (s, 1H), 9.55 (s, 1H). 1H).
References
[1] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 6, p. 650 - 654
[2] Patent: WO2008/135826, 2008, A2. Location in patent: Page/Page column 157; 158
[3] Patent: US2014/107094, 2014, A1. Location in patent: Paragraph 0625; 0626
[4] Patent: US2015/105372, 2015, A1. Location in patent: Paragraph 0304; 0305
[5] Patent: WO2015/57206, 2015, A1. Location in patent: Page/Page column 74; 75
1-Methyl-1H-1,2,3-triazole-5-carbaldehyde Preparation Products And Raw materials
Raw materials
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