1-(DiMethylsulfaMoyl)pyrazole

Product Name: 1-(DiMethylsulfaMoyl)pyrazole
CAS No.: 133228-21-4
Chemical Name: 1-(DiMethylsulfaMoyl)pyrazole
Synonyms: N,N-dimethyl-1H-Pyrazole-1-sulfonamide;1-(DiMethylsulfaMoyl)pyrazole;N,N-dimethylpyrazole-1-sulfonamide;1-(N,N-diMethyl-sulfaMoyl)pyrazole;1H-Pyrazole-1-sulfonamide, N,N-dimethyl-;N,N-dimethyl-1H-pyrazole-1-sulfonamide 97%
CBNumber: CB52597415
Molecular Formula: C5H9N3O2S
Formula Weight: 175.21
MOL File: 133228-21-4.mol

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1-(DiMethylsulfaMoyl)pyrazole Property

Melting point:: 118.5 °C
Boiling point:: 287.4±23.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -2.65±0.12(Predicted)
Appearance: Colorless to light yellow Solid-Liquid Mixture
InChI: InChI=1S/C5H9N3O2S/c1-7(2)11(9,10)8-5-3-4-6-8/h3-5H,1-2H3
InChIKey: RFYSRCRZAGKOIY-UHFFFAOYSA-N
SMILES: N1(S(N(C)C)(=O)=O)C=CC=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: D480335
Product name: 1-(Dimethylsulfamoyl)pyrazole
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: Z9694
Product name: 1-(Dimethylsulfamoyl)pyrazole
Packaging: 5g
Price: $243
Updated: 2021/12/16

AK Scientific

Product number: Z9694
Product name: 1-(Dimethylsulfamoyl)pyrazole
Packaging: 25g
Price: $794
Updated: 2021/12/16

Oakwood

Product number: 364055
Product name: N,N-Dimethyl-1H-pyrazole-1-sulfonamide
Purity: 95+%
Packaging: 25g
Price: $990
Updated: 2021/12/16

Ambeed

Product number: A177821
Product name: N,N-Dimethyl-1H-pyrazole-1-sulfonamide
Purity: 97%
Packaging: 250mg
Price: $25
Updated: 2021/12/16

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1-(DiMethylsulfaMoyl)pyrazole Chemical Properties,Usage,Production

Synthesis

288-13-1

13360-57-1

133228-21-4

The general procedure for the synthesis of 1-(N,N-dimethyl-sulfonyl)pyrazole from pyrazole and N,N-dimethylaminosulfonyl chloride is as follows: Example 80: Synthesis of 2-amino-1-(4-chlorophenyl)-1-[4-(3-ethyl-1H-pyrazol-4-yl)phenyl]ethanol Step 80A: Preparation of pyrazole-1-sulfonic acid dimethylamide To a solution of pyrazole (4.8 g, 81.9 mmol) in acetonitrile (125 mL) was sequentially added 1,4-diazabicyclo[2.2.2]octane (DABCO, 10.1 g, 90.3 mmol) and N,N-dimethanaminosulfonyl chloride (8.8 mL, 82.9 mmol). The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction solution was concentrated in vacuum and the residue was partitioned with water and ethyl acetate. The organic layer was separated, washed sequentially with 2N hydrochloric acid and saturated brine, and dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to afford 1-(N,N-dimethyl-sulfonyl)pyrazole as a colorless oil (13.1 g, 91% yield). LC/MS (PS-A2) retention time 2.16 min, [M+H]+ 176.

References

[1] Synthesis, 2006, # 5, p. 793 - 798
[2] Chemistry - An Asian Journal, 2015, vol. 10, # 8, p. 1626 - 1630
[3] Advanced Synthesis and Catalysis, 2014, vol. 356, # 7, p. 1555 - 1561
[4] Patent: WO2006/136830, 2006, A1. Location in patent: Page/Page column 190-191
[5] Patent: WO2006/136829, 2006, A2. Location in patent: Page/Page column 129

1-(DiMethylsulfaMoyl)pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(DiMethylsulfaMoyl)pyrazole Suppliers

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133228-21-4