MK 0343
- Product Name
- MK 0343
- CAS No.
- 233275-76-8
- Chemical Name
- MK 0343
- Synonyms
- MK 0343;MRK-409;MK0343,MK 0343;MK-0343 >=98% (HPLC);7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazo[4,3-b]pyridazine;7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine;1,2,4-Triazolo[4,3-b]pyridazine, 7-cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-Methyl-1H-1,2,4-triazol-5-yl)Methoxy]-
- CBNumber
- CB52603000
- Molecular Formula
- C19H17F2N7O
- Formula Weight
- 397.38
- MOL File
- 233275-76-8.mol
MK 0343 Property
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 2.11±0.10(Predicted)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0565
- Product name
- MK-0343
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $525
- Updated
- 2025/07/31
- Product number
- SML0565
- Product name
- MK-0343
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $133
- Updated
- 2022/05/15
- Product number
- 4415
- Product name
- MK0343
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 4415
- Product name
- MK0343
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $900
- Updated
- 2021/12/16
- Product number
- M425143
- Product name
- MK0343
- Packaging
- 1mg
- Price
- $110
- Updated
- 2021/12/16
MK 0343 Chemical Properties,Usage,Production
Uses
MK 0343 is a subtype-selective partial GABAA receptor agonist with the ability to cause anxiolytic and non-sedating properties.
Biological Activity
MK-0343 (MRK-409) is a partial agonist for GABAA receptors with comparable Ki values for α1, α2, α3 and α5 containing receptors (0.2 – 0.4 nM). The compound has the greatest agonist activity against α3 receptors, and is brain penatrant, and displays anxiolytic activity in rodent and primate models.
in vivo
MK0343 readily penetrates the brain in rats and occupies the benzodiazepine site of GABAA receptors, measured using an in vivo [3H]flumazenil binding assay, with an Occ50 of 2.2 mg/kg p.o. and a corresponding plasma EC50 of 115 ng/mL[1].
| Animal Model: | Male Sprague-Dawley rats (approximately 250–300g) (pharmacokinetics)[1] |
| Dosage: | 1, 2 or 3?mg/kg |
| Administration: | Oral administration |
| Result: | Readily penetrated the brain in rats and occupies the benzodiazepine site of GABAA receptors, with an Occ50 of 2.2?mg/kg p.o. and a corresponding plasma EC50 of 115?ng/mL. |
MK 0343 Preparation Products And Raw materials
Raw materials
Preparation Products
MK 0343 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58