4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE
- Product Name
- 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE
- CAS No.
- 89720-77-4
- Chemical Name
- 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE
- Synonyms
- 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE;Benzene, 4-bromo-1-(bromomethyl)-2-chloro-
- CBNumber
- CB52603343
- Molecular Formula
- C7H5Br2Cl
- Formula Weight
- 284.38
- MOL File
- 89720-77-4.mol
4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Colourless
Safety
- RIDADR
- 3265
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 2903998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- B680610
- Product name
- 4-Bromo-1-bromomethyl-2-chlorobenzene
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- FB19052
- Product name
- 4-Bromo-1-bromomethyl-2-chlorobenzene
- Packaging
- 10g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 119429
- Product name
- 4-Bromo-1-(bromomethyl)-2-chlorobenzene
- Purity
- 95+%
- Packaging
- 5g
- Price
- $324
- Updated
- 2021/12/16
- Product number
- FB19052
- Product name
- 4-Bromo-1-bromomethyl-2-chlorobenzene
- Packaging
- 25g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- HCH0365493
- Product name
- 4-BROMO-1-(BROMOMETHYL)-2-CHLOROBENZENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.75
- Updated
- 2021/12/16
4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE Chemical Properties,Usage,Production
Uses
4-Bromo-1-bromomethyl-2-chlorobenzene is used in the preparation of selective aldose reductase inhibitors.
Synthesis
185315-48-4
89720-77-4
To a solution of (4-bromo-2-chlorophenyl)methanol (2.80 g, 12.67 mmol) in dichloromethane (60.0 mL) was added sequentially carbon tetrabromide (4.41 g, 13.30 mmol) and triphenylphosphine (3.48 g, 13.30 mmol) under argon protection and at 0 °C. The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the resulting crude product was purified by fast column chromatography (eluent: hexane solution of 10% ethyl acetate) to afford 2-chloro-4-bromobenzyl bromide as a colorless oil (3.59 g, 100% yield).1H NMR (400 MHz, CDCl3): δ 4.53 (s, 2H), 7.29 (d, J = 8.2 Hz. 1H), 7.39 (dd, J = 8.2, 1.9 Hz, 1H), 7.56 (d, J = 1.9 Hz, 1H).
References
[1] Patent: WO2004/74270, 2004, A2. Location in patent: Page 175
[2] Patent: WO2006/18725, 2006, A1. Location in patent: Page/Page column 235-236
[3] Patent: WO2008/18827, 2008, A1. Location in patent: Page/Page column 65-66
[4] Patent: WO2010/15652, 2010, A2. Location in patent: Page/Page column 68
[5] Tetrahedron Letters, 2016, vol. 57, # 3, p. 449 - 451
4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE manufacturers
- Product
- 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE 89720-77-4
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-28