Methyl 4-chloro-5-Methylpicolinate
- Product Name
- Methyl 4-chloro-5-Methylpicolinate
- CAS No.
- 1104455-41-5
- Chemical Name
- Methyl 4-chloro-5-Methylpicolinate
- Synonyms
- Methyl 4-chloro-5-Methylpicolinate;Methyl 4-chloro-5-methylpyridine-2-carboxylate;4-Chloro-5-methylpyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 4-chloro-5-methyl-, methyl ester
- CBNumber
- CB52605231
- Molecular Formula
- C8H8ClNO2
- Formula Weight
- 185.61
- MOL File
- 1104455-41-5.mol
Methyl 4-chloro-5-Methylpicolinate Property
- Boiling point:
- 287.7±35.0 °C(Predicted)
- Density
- 1.247±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.04±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B495148
- Product name
- Methyl4-Chloro-5-methylpicolinate
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B495148
- Product name
- Methyl4-Chloro-5-methylpicolinate
- Packaging
- 5mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B495148
- Product name
- Methyl4-Chloro-5-methylpicolinate
- Packaging
- 25mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- X8939
- Product name
- Methyl4-chloro-5-methylpicolinate
- Packaging
- 100mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- HCH0369419
- Product name
- METHYL-4-CHLORO-5-METHYLPICOLINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.97
- Updated
- 2021/12/16
Methyl 4-chloro-5-Methylpicolinate Chemical Properties,Usage,Production
Synthesis
67-56-1
4434-13-3
1104455-41-5
1. 5-methylpyridine carboxylic acid (13.7 g) was mixed with thionyl chloride (150 mL) under nitrogen protection, sodium bromide (20.6 g) was added in batches and heated to reflux for 1 hour. 2. DMF (2 mL) was added and refluxing continued under nitrogen protection for 16 hours. 3. Toluene (100 mL) was added to the reaction mixture and the solvent was evaporated under reduced pressure, this operation was repeated twice. Subsequently, toluene (100 mL) was added to the residue. 4. DIPEA (25.8 g) and methanol (20 mL) were added to the above mixture under nitrogen protection and at 0 °C, followed by stirring at 20 °C for 2 hours. 5. The solvent was evaporated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether) to afford methyl 4-chloro-5-methylpyridinecarboxylate (9.40g). 6. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 2.43 (3H, s), 3.99 (3H, s), 8.10 (1H, s), 8.54 (1H, s).
References
[1] Patent: EP3156397, 2017, A1. Location in patent: Paragraph 0267
[2] Patent: WO2018/89261, 2018, A2. Location in patent: Paragraph 0932; 0933; 0934
Methyl 4-chloro-5-Methylpicolinate Preparation Products And Raw materials
Raw materials
Preparation Products
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