2,6-dibroMo-3-Methoxy-5-nitropyridine
- Product Name
- 2,6-dibroMo-3-Methoxy-5-nitropyridine
- CAS No.
- 79491-46-6
- Chemical Name
- 2,6-dibroMo-3-Methoxy-5-nitropyridine
- Synonyms
- 2,6-dibroMo-3-Methoxy-5-nitropyridine;Pyridine, 2,6-dibromo-3-methoxy-5-nitro-
- CBNumber
- CB52605983
- Molecular Formula
- C6H4Br2N2O3
- Formula Weight
- 311.92
- MOL File
- 79491-46-6.mol
2,6-dibroMo-3-Methoxy-5-nitropyridine Property
- Melting point:
- 113-114 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 342.5±37.0 °C(Predicted)
- Density
- 2.067±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -12.06±0.10(Predicted)
- Appearance
- Light yellow to orange Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0362896
- Product name
- 2,6-DIBROMO-3-METHOXY-5-NITROPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.36
- Updated
- 2021/12/16
- Product number
- 5635BB
- Product name
- 2,6-Dibromo-3-methoxy-5-nitropyridine
- Packaging
- 10g
- Price
- $1154
- Updated
- 2021/12/16
- Product number
- A178992
- Product name
- 2,6-Dibromo-3-methoxy-5-nitropyridine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $33
- Updated
- 2021/12/16
- Product number
- A178992
- Product name
- 2,6-Dibromo-3-methoxy-5-nitropyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- A178992
- Product name
- 2,6-Dibromo-3-methoxy-5-nitropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
2,6-dibroMo-3-Methoxy-5-nitropyridine Chemical Properties,Usage,Production
Synthesis
79491-45-5
79491-46-6
The general procedure for the synthesis of 2,6-dibromo-3-methoxy-5-nitropyridine using 2,6-dibromo-3-methoxypyridine as starting material was as follows: first, concentrated sulfuric acid (16 mL) was slowly added to the reaction vessel at 0 °C. Subsequently, 2,6-dibromo-3-methoxypyridine (3.4 g, 13 mmol) was added in batches, and the process was completed within 20 min. Next, 90% fuming nitric acid (16 mL, 318 mmol) was added dropwise to the reaction system. After installing a reflux condenser, the reaction mixture was gradually warmed to room temperature, then heated to 65 °C and maintained at this temperature for 2 hours. Upon completion of the reaction, the mixture was slowly poured into a 500 mL beaker containing ice. After the ice was completely melted, the mixture was vacuum filtered and the resulting solid was washed with a small amount of cold water. Finally, the collected solid was dried under vacuum to afford the target product 2,6-dibromo-3-methoxy-5-nitropyridine (1.67 g, 5.4 mmol) in 42% yield as a light yellow solid.
References
[1] Australian Journal of Chemistry, 1981, vol. 34, # 4, p. 927 - 932
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 24, p. 5630 - 5634
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 15, p. 4298 - 4311
[4] Patent: EP2017277, 2009, A1. Location in patent: Page/Page column 30
2,6-dibroMo-3-Methoxy-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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