1H-Indole, 4-chloro-6-fluoro-

Product Name: 1H-Indole, 4-chloro-6-fluoro-
CAS No.: 885520-79-6
Chemical Name: 1H-Indole, 4-chloro-6-fluoro-
Synonyms: 4-CHLORO-6-FLUORO-1H-INDOLE;1H-Indole, 4-chloro-6-fluoro-;Stannane,tetrakis(4-methylethoxy)-
CBNumber: CB52606490
Molecular Formula: C8H5ClFN
Formula Weight: 169.58
MOL File: 885520-79-6.mol

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1H-Indole, 4-chloro-6-fluoro- Property

Boiling point:: 289.5±20.0 °C(Predicted)
Density: 1.436±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 15.50±0.30(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: C384665
Product name: 4-Chloro-6-fluoro-1H-indole
Packaging: 5mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-7-0L
Product name: 4-Chloro-6-fluoro-1H-indole
Purity: 95.0%
Packaging: 250mg
Price: $284
Updated: 2021/12/16

Apolloscientific

Product number: PC903779
Product name: 4-Chloro-6-fluoro-1H-indole
Purity: 95+%
Packaging: 100mg
Price: $111
Updated: 2021/12/16

Apolloscientific

Product number: PC903779
Product name: 4-Chloro-6-fluoro-1H-indole
Purity: 95+%
Packaging: 250mg
Price: $177
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H37-7-0L
Product name: 4-Chloro-6-fluoro-1H-indole
Purity: 95.0%
Packaging: 100mg
Price: $178
Updated: 2021/12/16

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1H-Indole, 4-chloro-6-fluoro- Chemical Properties,Usage,Production

Synthesis

108-05-4

1431711-55-5

885520-79-6

General procedure for the synthesis of 4-chloro-6-fluoro-1H-indole from vinyl acetate and compound (CAS: 1431711-55-5): (c) 4-chloro-6-fluoro-1H-indole N-(3-chloro-5-fluoro-phenyl)-N-hydroxy-acetamide (200 mg, 982 μmol) was dissolved in vinyl acetate (1.81 mL, 19.6 mmol) in vinyl acetate (1.81 mL, 19.6 mmol), followed by addition of Li2PdCl4 (25.7 mg, 98 μmol). The reaction mixture was stirred at 60 °C for 3 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and brine; the organic layer was separated and concentrated under reduced pressure to obtain a solid. The solid was dissolved in 8 mL of methanol (MeOH), 1N aqueous sodium hydroxide solution (1.89 mL, 1.89 mmol) was added, and stirred at room temperature for 2 hours. The reaction mixture was quenched with 2N aqueous hydrochloric acid (0.95 mL, 1.9 mmol) followed by the addition of 300 mg of sodium carbonate (Na2CO3). After addition of 50 mL of ethyl acetate (EtOAc), the organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. The residue was purified by column chromatography (12 g silica gel (SiO2); ethyl acetate/heptane, gradient from 0/100 to 1/4) to afford the title compound as a liquid (72 mg, 45% yield, two steps).1H-NMR (DMSO-d6): δ 11.52 (brs, 1H), 7.45 (d, 1H), 7.20 (d, 1H), 7.05 (d, 1H), 6.45 (d, 1H).

References

[1] Patent: WO2013/61305, 2013, A1. Location in patent: Page/Page column 47

1H-Indole, 4-chloro-6-fluoro- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Indole, 4-chloro-6-fluoro- Suppliers

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885520-79-6, 1H-Indole, 4-chloro-6-fluoro-Related Search:

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4-CHLORO-6-FLUORO-1H-INDOLE

1H-Indole, 4-chloro-6-fluoro-

Stannane,tetrakis(4-methylethoxy)-

885520-79-6