1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-
- Product Name
- 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-
- CAS No.
- 633328-98-0
- Chemical Name
- 1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-
- Synonyms
- 5-CHLORO-1H-PYRAZOLO[4,3-D]PYRIMIDINE;5-Chloropyrazolo[4,3-d]pyrimidine;1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro-
- CBNumber
- CB52607295
- Molecular Formula
- C5H3ClN4
- Formula Weight
- 154.56
- MOL File
- 633328-98-0.mol
1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- Property
- Density
- 1.653±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 6.68±0.50(Predicted)
- form
- solid
- color
- Yellow
- InChI
- InChI=1S/C5H3ClN4/c6-5-7-1-4-3(9-5)2-8-10-4/h1-2H,(H,8,10)
- InChIKey
- MRTKTXTWOUDUTL-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C2NN=CC2=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- C384415
- Product name
- 5-Chloro-1H-pyrazolo[4,3-D]pyrimidine
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 6394DP
- Product name
- 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $193
- Updated
- 2021/12/16
- Product number
- OR305533
- Product name
- 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $112
- Updated
- 2021/12/16
- Product number
- 3H31-5-09
- Product name
- 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- FC153489
- Product name
- 5-Chloro-1h-pyrazolo[4,3-d]pyrimidine
- Packaging
- 500mg
- Price
- $760
- Updated
- 2021/12/16
1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- Chemical Properties,Usage,Production
Uses
5-Chloro-1H-pyrazolo[4,3-D]pyrimidine is used in preparation of pyrimidine derivatives and related heterocycles as DNA-dependent protein kinase inhibitors for treatment of diseases.
Synthesis
633328-97-9
633328-98-0
General procedure for the synthesis of 5-chloro-1H-pyrazolo[4,3-d]pyrimidin-1-yl from 1-(5-chloro-1H-pyrazolo[4,3-d]pyrimidin-1-yl)ethanone: To a stirred solution of 1-(5-chloro-1H-pyrazolo[4,3-d]pyrimidin-1-yl)ethanone (1.5 g, 7.65 mmol) in tetrahydrofuran (THF, 15 mL), was added an 8% hydrochloric acid aqueous solution (14.46 mL). The reaction mixture was refluxed at 50 °C for 30 min. After completion of the reaction, it was cooled to 25 °C and extracted with ethyl acetate (EtOAc, 2 × 50 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford 5-chloro-1H-pyrazolo[4,3-d]pyrimidine as an off-white solid (1.1 g, 93% yield). Mass spectrum (ESI): m/z = 153.0 [M-H]-.
References
[1] Patent: WO2017/137334, 2017, A1. Location in patent: Page/Page column 123; 124
[2] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0035
[3] Patent: US2012/202785, 2012, A1. Location in patent: Page/Page column 263
1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyrazolo[4,3-d]pyriMidine, 5-chloro- Suppliers
- Tel
- 15221020695
- 502277408@qq.com
- Country
- China
- ProdList
- 459
- Advantage
- 58
- Tel
- 18151128828
- Fax
- -
- hc-sales@foxmail.com
- Country
- China
- ProdList
- 2648
- Advantage
- 55
- Tel
- 18083715844
- sales@milonpharm.com
- Country
- China
- ProdList
- 291
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
- Tel
- 021-64968085,64968086-5815,5812; 13472757003
- Fax
- +86 21 64968087
- xiaoxia.zeng@rainbowpharma.cn
- Country
- China
- ProdList
- 961
- Advantage
- 65
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9519
- Advantage
- 58
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 40000
- Advantage
- 60
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14917
- Advantage
- 59
- Tel
- 13817873692
- Fax
- 021-31329586
- mkt@boynerspharm.com
- Country
- China
- ProdList
- 1707
- Advantage
- 55
- Tel
- 28-87999436 02887999436
- Fax
- QQ:2746983436
- sales@sano-chem.com
- Country
- China
- ProdList
- 3795
- Advantage
- 55