3-(phenylsulfonylMethylene)oxetane
- Product Name
- 3-(phenylsulfonylMethylene)oxetane
- CAS No.
- 1221819-46-0
- Chemical Name
- 3-(phenylsulfonylMethylene)oxetane
- Synonyms
- 3-((Phenylsulfonyl);3-(phenylsulfonylMethylene)oxetane;3-(Benzenesulfonylmethylene)oxetane;3-[(Phenylsulphonyl)methylidene]oxetane;Oxetane, 3-[(phenylsulfonyl)methylene]-;3-[(benzenesulfonyl)methylidene]oxetane
- CBNumber
- CB52609754
- Molecular Formula
- C10H10O3S
- Formula Weight
- 210.25
- MOL File
- 1221819-46-0.mol
3-(phenylsulfonylMethylene)oxetane Property
- Melting point:
- 51-53 °C
- Boiling point:
- 412.0±45.0 °C(Predicted)
- Density
- 1.412±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 29041000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B481513
- Product name
- 3-((Phenylsulfonyl)methylene)oxetane
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B481513
- Product name
- 3-((Phenylsulfonyl)methylene)oxetane
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 3518DG
- Product name
- 3-((Phenylsulfonyl)methylene)oxetane
- Packaging
- 1g
- Price
- $354
- Updated
- 2021/12/16
- Product number
- CHM1050415
- Product name
- 3-((PHENYLSULFONYL)METHYLENE)OXETANE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $459.34
- Updated
- 2021/12/16
- Product number
- 118198
- Product name
- 3-((Phenylsulfonyl)methylene)oxetane
- Packaging
- 1g
- Price
- $474
- Updated
- 2021/12/16
3-(phenylsulfonylMethylene)oxetane Chemical Properties,Usage,Production
Synthesis
6704-31-0
3112-85-4
1221819-46-0
General procedure: n-Butyl lithium (n-BuLi, 2.5 M hexane solution, 12.2 mL, 30.6 mmol) was slowly added dropwise to a solution of (methylsulfonyl)benzene (2.2 g, 13.9 mmol) in tetrahydrofuran (THF, 38 mL) at 0 °C, with the dropwise addition time being controlled at 10 minutes. After the dropwise addition, the reaction mixture was continued to be stirred for 30 minutes. Subsequently, chlorodiethylphosphonate (2.4 mL, 16.7 mmol) was added dropwise to the reaction system.After 30 min, oxetan-3-one (1.0 g, 13.9 mmol) was dissolved in THF (2 mL) and slowly added dropwise to the reaction mixture at -78 °C. After completion of the dropwise addition, the reaction mixture was stirred continuously at -78 °C for 2 hours. At the end of the reaction, the reaction mixture was diluted with aqueous ammonium chloride (NH4Cl) (100 mL) and extracted with ethyl acetate (EtOAc, 100 mL x 2). The organic layers were combined, concentrated and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=3/1) to afford the target product 3-((phenylsulfonyl)methylene)oxetane (2.4 g, 82% yield) as a colorless oil.1H NMR (400 MHz, CDCl3): δ 7.90-7.88 (m, 2H), 7.68- 7.64 (m, 1H), 7.57 (t, J=7.6Hz, 2H), 6.13-6.11 (m, 1H), 5.66-5.64 (m, 2H), 5.30-5.27 (m, 2H).
References
[1] Patent: WO2018/137619, 2018, A1. Location in patent: Page/Page column 54; 55
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 8, p. 3227 - 3246
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8540 - 8562
[4] Patent: US2015/238473, 2015, A1. Location in patent: Paragraph 0271
[5] Patent: WO2013/16197, 2013, A1. Location in patent: Page/Page column 92
3-(phenylsulfonylMethylene)oxetane Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(phenylsulfonylMethylene)oxetane manufacturers
- Product
- 3-(phenylsulfonylMethylene)oxetane 1221819-46-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-22