3',4',5'-trifluorobiphenyl-2-aMine

Product Name: 3',4',5'-trifluorobiphenyl-2-aMine
CAS No.: 915416-45-4
Chemical Name: 3',4',5'-trifluorobiphenyl-2-aMine
Synonyms: Fluxapyroxad-002;3,4,5-Trifluoro-2'-aminobiphenyl;2-(3,4,5-Trifluorophenyl)aniline;3',4',5'-trifluoro-2-aminobiphenyl;3',4',5'-trifluorobiphenyl-2-aMine;3',4',5'-Trifluorobiphenyl-2-ylamine;3',4',5'-trifluoro-[1,1'-biphenyl]-2-am;3',4',5'-trifluoro-[1,1'-biphenyl]-2-am;3',4',5'-trifluoro-[1,1'-biphenyl]-2-aMine;[1,1'-Biphenyl]-2-amine, 3',4',5'-trifluoro-
CBNumber: CB52609769
Molecular Formula: C12H8F3N
Formula Weight: 223.19
MOL File: 915416-45-4.mol

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3',4',5'-trifluorobiphenyl-2-aMine Property

Boiling point:: 303.7±37.0 °C(Predicted)
Density: 1.315
storage temp.: 2-8°C(protect from light)
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 2.17±0.10(Predicted)
form: Solid
color: Off-White to Light Beige
InChI: InChI=1S/C12H8F3N/c13-9-5-7(6-10(14)12(9)15)8-3-1-2-4-11(8)16/h1-6H,16H2
InChIKey: FTIKVBVUYPQUBF-UHFFFAOYSA-N
SMILES: C1(C2=CC(F)=C(F)C(F)=C2)=CC=CC=C1N
EPA Substance Registry System: [1,1'-Biphenyl]-2-amine, 3',4',5'-trifluoro- (915416-45-4)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: T304270
Product name: 3'',4'',5''-Trifluoro-[1,1''-biphenyl]-2-amine
Packaging: 500mg
Price: $180
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0364083
Product name: 3',4',5'-TRIFLUORO-[1,1'-BIPHENYL]-2-AMINE
Purity: 95.00%
Packaging: 100MG
Price: $274.05
Updated: 2021/12/16

AK Scientific

Product number: W9483
Product name: 3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine
Packaging: 10g
Price: $1330
Updated: 2021/12/16

AK Scientific

Product number: W9483
Product name: 3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine
Packaging: 25g
Price: $2353
Updated: 2021/12/16

Alichem

Product number: 1214360572
Product name: 3',4,5-Trifluorobiphenyl-2-amine
Packaging: 1g
Price: $1445.3
Updated: 2021/12/16

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3',4',5'-trifluorobiphenyl-2-aMine Chemical Properties,Usage,Production

Uses

3'',4'',5''-Trifluoro-[1,1''-biphenyl]-2-amine is a building block used in various chemical synthesis.

Flammability and Explosibility

Non flammable

Synthesis

884-29-7

156006-28-9

915416-45-4

In a 1 liter reactor, zinc chloride (20 g, 0.147 mol) was mixed with THF (29 g) and heated to a suitable temperature. Subsequently, a THF solution (1.15 mmol/g solution) of 3,4,5-trifluorophenylmagnesium bromide (0.133 mol) was added. After stirring for 10 min, (1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)(3-chloropyridyl)-palladium(II) dichloride (462 mg) was added at 25 °C. After 5 min, N-methylpyrrolidone (30 g) was added. after 10 min, phenylmethylideneamino-2-chlorobenzene, 99% pure, was added to the reaction mixture (29 g, 0.133 moles). Subsequently, the mixture was heated to 50 °C and stirred at this temperature for 6 hours. The post-treatment step consisted of adding 3.4 g of activated carbon, stirring the suspension for 1 hour and then filtering through diatomaceous earth. The filter cake was washed with THF (200 g) and the filtrate was subsequently concentrated. Concentration was carried out using a rotary evaporator at 50 °C and a vacuum below 5 mbar. Water (200 g) and concentrated sulfuric acid (28 g) were added to the residue. The mixture was stirred at 80 °C for 3 h while the generated benzaldehyde was removed by azeotropic distillation. Afterwards, the pH was adjusted to 2.8 with sodium hydroxide solution and toluene (200 g) was added. After separation of the organic phase, the aqueous phase was re-extracted with toluene (200 g) and the combined organic phases were washed with water (100 g) and concentrated. Concentration at 80 °C and 5 mbar using a rotary evaporator yielded a dark colored oil (26.7 g), which crystallized after standing. Quantitative HPLC analysis showed 86.4% by weight of 3,4,5-trifluoro-2'-aminobiphenyl in the oily substance, corresponding to 78% yield.

References

[1] Patent: US2011/301356, 2011, A1. Location in patent: Page/Page column 10

3',4',5'-trifluorobiphenyl-2-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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3',4',5'-trifluorobiphenyl-2-aMine Suppliers

China 131 India 2 United States 3 Global 136

Fuyang Sineva Pharmaceutical Co., Ltd

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Email: dingzhikui@sineva.com.cn
Country: China
ProdList: 47
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Dalian Zhuorui Biological Technology Co. LTD

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LinkChem Technology Co., Ltd.

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YANGZHOU HENGCHUAN CHEMICAL CO., LTD.

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Country: China
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Hebei Maison Chemical Co.,Ltd.

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Country: China
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Jinan Gaochun Pharmaceutical Technology Co., Ltd.

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Shanghai Harvest Chemical Industrial Co., Ltd.

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Fax: +86-21-51385350
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Country: China
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DKD Shijiazhuang Chemical Co., Ltd.

Tel: 0311-0311-67790228 15531158659
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Shanghai Topbiochem Technology Co., Ltd

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View Lastest Price from 3',4',5'-trifluorobiphenyl-2-aMine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3',4',5'-trifluorobiphenyl-2-aMine 915416-45-4
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-09-05

Shaanxi Dideu New Materials Co. Ltd

Product: 3',4',5'-trifluorobiphenyl-2-amine 915416-45-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-08-21

PNP Biotech Co. Ltd

Product: 3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine 915416-45-4
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-10-18

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915416-45-4

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