Oritavancin Diphosphate
Clinical Effects- Product Name
- Oritavancin Diphosphate
- CAS No.
- 192564-14-0
- Chemical Name
- Oritavancin Diphosphate
- Synonyms
- OC/ QTH05;LY 333328 diphosphate;Oritavancin (phosphate);Oritavancin Diphosphate;LY 333328;ORITAVANCIN (PHOSPHATE);Oritavancin diphosphate (LY333328);oritavancin,LY333328 diphosphate salt;(4''R)-22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-N3''-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]-Vancomycin phosphate (1:2);Vancomycin, 22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-arabino-hexopyranosyl)-N3''-[(4'-chloro[1,1'-biphenyl]-4-yl)methyl]-, (4''R)-, phosphate (1:2)
- CBNumber
- CB52611438
- Molecular Formula
- C86H103Cl3N10O34P2
- Formula Weight
- 1989.091142
- MOL File
- 192564-14-0.mol
Oritavancin Diphosphate Property
- Melting point:
- >229°C (dec.)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML1586
- Product name
- Oritavancin diphosphate
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- SML1586
- Product name
- Oritavancin diphosphate
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $435
- Updated
- 2024/03/01
- Product number
- 24091
- Product name
- Oritavancin (phosphate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 24091
- Product name
- Oritavancin (phosphate)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 24091
- Product name
- Oritavancin (phosphate)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $385
- Updated
- 2024/03/01
Oritavancin Diphosphate Chemical Properties,Usage,Production
Clinical Effects
Oritavancin diphosphate will most probably be prescribed as a once-daily dose and it demonstrates concentration-dependent bactericidal activity. Various clinical studies of oritavancin diphosphate have shown good performance. Oritavancin diphosphate has demonstrated preliminary safety and efficacy in Phase I and II clinical trials. In a Phase III clinical trial, oritavancin diphosphate has achieved the primary efficacy end point in the treatment of complicated Gram-positive skin and skin-structure infections. To date, adverse events have been mild and limited; the most common being administration site complaints, headache, rhinitis, dry skin, pain, increases in liver transaminases and accumulation of free cholesterol and phospholipids in phagocytic (macrophages) and nonphagocytic (fibroblast) cells.
Description
Oritavancin diphosphate is a glycopeptide analog related to the vancomycin class of antibiotics that inhibits the transpeptidase and transglycosylation steps of bacterial peptidoglycan cell-wall synthesis. The compound was discovered and initially developed by Eli Lilly and Co. The development of the compound was sold to Intermune and then to Targanta which was acquired by The Medicines Company who achieved approval of the drug by the US FDA for the treatment of acute bacterial skin and skin-structure infections caused by gram-positive bacteria. It is also approved for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections.
Uses
Oritavancin phosphate can be used in biological study of synthesis, properties, and mechanism of action of new generation of polycyclic glycopeptide antibiotics.
Uses
Antibacterial (peptidoglycan synthesis inhibitor).
Definition
ChEBI: A phosphate salt obtained by combining oritavancin with two molar equivalents of phosphoric acid. Used for the treatment of acute bacterial skin and skin structure infections caused or suspected to be caused by susceptible isolates of designated Gram-posit ve microorganisms.
Biochem/physiol Actions
Oritavancin is a lipoglycopeptide vancomycin analog with broad spectrum activity against gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and organisms resistant to vancomycin and other antibiotics such as linezolid and daptomycin. Oritavancin has multiple mechanisms of action, including inhibition of transglycosylation, inhibition of transpeptidation, and cell membrane interaction/disruption. Oritavancin also has a long half-life, allowing for a single intravenous dose of rather than the standard vacomycin treatment of twice-daily infusions for ten days.
Synthesis
Commercial eremomycin (217) was treated with 40-chlorobiphenylcarboxaldehyde (218) followed by sodium cyanoborohydride in refluxing methanol to give oritavancin. Interestingly, there are three amino groups within eremomycin that can undergo reductive alkylation, and this chemistry preferentially occurs at the disaccharide amino group. The reaction is reported to occur in 69% crude yield and giving 16¨C18% yield of oritavancin after high performance liquid chromatography (HPLC) purification. No experimental details were found describing the preparation of the diphosphate salt, but presumably this occurs through treatment with phosphoric acid and crystallization to give oritavancin diphosphate (XXVI).
Oritavancin Diphosphate Preparation Products And Raw materials
Raw materials
Preparation Products
Oritavancin Diphosphate Suppliers
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View Lastest Price from Oritavancin Diphosphate manufacturers
- Product
- Oritavancin diphosphate 192564-14-0
- Price
- US $10.00/g/Bag
- Min. Order
- 10g
- Purity
- 99
- Supply Ability
- 100KG
- Release date
- 2021-11-16
- Product
- oritavancin bisphosphate 192564-14-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- Oritavancin Diphosphate 192564-14-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09