2-broMo-5-cyclopropylpyridine
- Product Name
- 2-broMo-5-cyclopropylpyridine
- CAS No.
- 1142197-14-5
- Chemical Name
- 2-broMo-5-cyclopropylpyridine
- Synonyms
- CAS:1142197-14-5;2-broMo-5-cyclopropylpyridine;Pyridine, 2-bromo-5-cyclopropyl-
- CBNumber
- CB52614444
- Molecular Formula
- C8H8BrN
- Formula Weight
- 198.06
- MOL File
- 1142197-14-5.mol
2-broMo-5-cyclopropylpyridine Property
- Boiling point:
- 259.0±28.0 °C(Predicted)
- Density
- 1.561±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.17±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B715008
- Product name
- 2-Bromo-5-cyclopropylpyridine
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- HCH0363228
- Product name
- 2-BROMO-5-CYCLOPROPYLPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.51
- Updated
- 2021/12/16
- Product number
- 0827DG
- Product name
- 2-Bromo-5-cyclopropylpyridine
- Packaging
- 2.5g
- Price
- $1198
- Updated
- 2021/12/16
- Product number
- A259491
- Product name
- 2-Bromo-5-cyclopropylpyridine
- Purity
- 98%
- Packaging
- 100mg
- Price
- $106
- Updated
- 2021/12/16
- Product number
- A259491
- Product name
- 2-Bromo-5-cyclopropylpyridine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $168
- Updated
- 2021/12/16
2-broMo-5-cyclopropylpyridine Chemical Properties,Usage,Production
Synthesis
893738-68-6
1142197-14-5
General method: 5-cyclopropylpyridin-2-amine (1 mmol) was dissolved in dibromo(chloro)methane (6 mL) with the corresponding Cu(II) halide (0.5 mmol) at 25 °C and under argon protection. Alkyl nitrite (1.1 mmol) was added slowly and dropwise over 5 min, followed by stirring of the reaction mixture at a suitable temperature (see Tables 1 and 2) until GC-MS analysis showed complete consumption of the feedstock. Upon completion of the reaction, the mixture was poured into 1N NaOH solution (20 mL), stirred for 1 h, and then extracted with dichloromethane (3 x 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography using dichloromethane as eluent. 2-Bromo-5-cyclopropylpyridine (2a): 76% yield. Thin layer chromatography Rf value was 0.49 (unfolding agent: dichloromethane). NMR hydrogen spectrum (400MHz, CDCl3) δ 8.17 (d, J=2.4Hz, 1H), 7.34 (d, J=8.2Hz, 1H), 7.15 (dd, J=8.2,2.4Hz, 1H), 1.89-1.82 (m, 1H), 1.10-0.98 (m, 2H), 0.75-0.64 (m, 2H) . NMR carbon spectrum (100 MHz, CDCl3) δ 148.6,138.8,138.7,135.4,127.5,12.5,9.1. GC-MS analysis: retention time tR = 7.031 min, mass-to-charge ratio m/z (relative abundance) 197 (43.52%), 199 (41.85%).
References
[1] Tetrahedron Letters, 2017, vol. 58, # 17, p. 1681 - 1683
2-broMo-5-cyclopropylpyridine Preparation Products And Raw materials
Raw materials
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