Methyl 2-(3-oxocyclobutyl)acetate
- Product Name
- Methyl 2-(3-oxocyclobutyl)acetate
- CAS No.
- 1148130-30-6
- Chemical Name
- Methyl 2-(3-oxocyclobutyl)acetate
- Synonyms
- Methyl 2-(3-oxocyclobutyl);ethyl 2-(3-oxocyclobutyl)acetate;Methyl 2-(3-oxocyclobutyl)acetate;Cyclobutaneacetic acid, 3-oxo-, methyl ester
- CBNumber
- CB52614848
- Molecular Formula
- C7H10O3
- Formula Weight
- 142.15
- MOL File
- 1148130-30-6.mol
Methyl 2-(3-oxocyclobutyl)acetate Property
- Boiling point:
- 205.7±13.0 °C(Predicted)
- Density
- 1.136±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Appearance
- colorless liquid
- InChI
- InChI=1S/C7H10O3/c1-10-7(9)4-5-2-6(8)3-5/h5H,2-4H2,1H3
- InChIKey
- UJPOOJZMVQMLOM-UHFFFAOYSA-N
- SMILES
- C1(CC(OC)=O)CC(=O)C1
Safety
- HS Code
- 2916200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M325343
- Product name
- Methyl2-(3-Oxocyclobutyl)acetate
- Packaging
- 50mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 120069
- Product name
- Methyl 2-(3-oxocyclobutyl)acetate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $389
- Updated
- 2021/12/16
- Product number
- Z3903
- Product name
- Methyl2-(3-oxocyclobutyl)acetate
- Packaging
- 250mg
- Price
- $449
- Updated
- 2021/12/16
- Product number
- CHM0392868
- Product name
- METHYL-2-(3-OXOCYCLOBUTYL)ACETATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.59
- Updated
- 2021/12/16
- Product number
- OR932724
- Product name
- Methyl 2-(3-oxocyclobutyl)acetate
- Packaging
- 500mg
- Price
- $693
- Updated
- 2021/12/16
Methyl 2-(3-oxocyclobutyl)acetate Chemical Properties,Usage,Production
Synthesis
1148130-29-3
1148130-30-6
Methyl 2-(2,2-dichloro-3-oxocyclobutyl)acetate (0.6 g) was used as raw material, which was dissolved in acetic acid (5 mL) and zinc powder (0.929 g) was added. The reaction mixture was stirred at 100 °C for 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate, and subsequently carefully neutralized with ice-cold saturated aqueous sodium bicarbonate solution at 0 °C. The aqueous phase was separated, extracted with ethyl acetate, the organic phases were combined and washed with saturated aqueous sodium bicarbonate solution. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by column chromatography on 40 g silica gel using a 20-minute gradient of 0-90% ethyl acetate/hexane solution as eluent, resulting in methyl 2-(3-oxocyclobutyl)acetate (0.27 g). The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts of 3.63 (3H, s), 3.12-3.27 (2H, m), 2.68-2.81 (3H, m), 2.56-2.64 (2H, m).
References
[1] Patent: US2009/118287, 2009, A1. Location in patent: Page/Page column 74-75
[2] Patent: US2013/183269, 2013, A1. Location in patent: Paragraph 1332; 1333
[3] Patent: WO2015/5901, 2015, A1. Location in patent: Page/Page column 540; 541
Methyl 2-(3-oxocyclobutyl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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