5-fluoropyriMidine-2-carbaldehyde
- Product Name
- 5-fluoropyriMidine-2-carbaldehyde
- CAS No.
- 935667-50-8
- Chemical Name
- 5-fluoropyriMidine-2-carbaldehyde
- Synonyms
- 5-fluoropyriMidine-2-carbaldehyde;5-FluoropyriMidine-2-carboxaldehyde;5-Fluoro-2-pyrimidinecarboxaldehyde;2-Pyrimidinecarboxaldehyde, 5-fluoro-
- CBNumber
- CB52616534
- Molecular Formula
- C5H3FN2O
- Formula Weight
- 126.09
- MOL File
- 935667-50-8.mol
5-fluoropyriMidine-2-carbaldehyde Property
- Boiling point:
- 272.3±32.0 °C(Predicted)
- Density
- 1.374±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.22±0.22(Predicted)
- Appearance
- Orange to red Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F600100
- Product name
- 5-Fluoropyrimidine-2-carbaldehyde
- Packaging
- 50mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 3220AJ
- Product name
- 5-Fluoropyrimidine-2-carbaldehyde
- Packaging
- 1g
- Price
- $1268
- Updated
- 2021/12/16
- Product number
- 122461
- Product name
- 5-Fluoropyrimidine-2-carboxaldehyde
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $1980
- Updated
- 2021/12/16
- Product number
- 4H15-3-37
- Product name
- 5-Fluoropyrimidine-2-carbaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $2267
- Updated
- 2021/12/16
- Product number
- 4H15-3-37
- Product name
- 5-Fluoropyrimidine-2-carbaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $843
- Updated
- 2021/12/16
5-fluoropyriMidine-2-carbaldehyde Chemical Properties,Usage,Production
Synthesis
38275-55-7
935667-50-8
General procedure for the synthesis of 5-fluoropyrimidine-2-carbaldehyde from 2-cyano-5-fluoropyrimidine: To an anhydrous THF solution of 5-fluoropyrimidine-2-carbonitrile (1.0 g, 8.1 mmol) was slowly added a solution of DIBAL-H (8.1 mL) over a period of 20 min at -78 °C. The reaction mixture was continued to be stirred at this temperature for 2 h. The reaction was subsequently quenched by the addition of MeOH. The reaction system was slowly warmed to room temperature and then concentrated HCl solution was added. The resulting mixture was stirred at room temperature for 2 h before being extracted with an aqueous layer and EtOAc (3 times). The combined organic phases were washed with brine and dried over MgSO4. The solvent was removed by concentration under reduced pressure to give 5-fluoropyrimidine-2-carbaldehyde (780 mg, 76% yield). Mass spectrometry result: [M+H]+ 127.
References
[1] Patent: WO2007/49041, 2007, A1. Location in patent: Page/Page column 71
[2] Patent: WO2008/117050, 2008, A1. Location in patent: Page/Page column 64
[3] Patent: WO2008/135786, 2008, A1. Location in patent: Page/Page column 53
[4] Patent: WO2013/142269, 2013, A1. Location in patent: Paragraph 0645; 0646; 0647
5-fluoropyriMidine-2-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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