2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE

Product Name: 2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE
CAS No.: 1192479-35-8
Chemical Name: 2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE
Synonyms: 2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE;Pyrimidine, 2-chloro-5-fluoro-4-methoxy-6-methyl-
CBNumber: CB52617344
Molecular Formula: C6H6ClFN2O
Formula Weight: 176.58
MOL File: 1192479-35-8.mol

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2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE Property

Boiling point:: 278.4±35.0 °C(Predicted)
Density: 1.334±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.33±0.39(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C989508
Product name: 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine
Packaging: 100mg
Price: $350
Updated: 2021/12/16

Apolloscientific

Product number: PC907736
Product name: 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine
Purity: 97%
Packaging: 100mg
Price: $89
Updated: 2021/12/16

Apolloscientific

Product number: PC907736
Product name: 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine
Purity: 97%
Packaging: 250mg
Price: $162
Updated: 2021/12/16

Crysdot

Product number: CD11334914
Product name: 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine
Purity: 95+%
Packaging: 250mg
Price: $222
Updated: 2021/12/16

Ambeed

Product number: A497420
Product name: 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine
Purity: 97%
Packaging: 1g
Price: $240
Updated: 2021/12/16

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2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

954220-98-5

124-41-4

1192479-35-8

To a solution of tetrahydrofuran (THF, 6 mL) containing 2,4-dichloro-5-fluoro-6-methylpyrimidine (563 mg, 3.11 mmol), a methanolic solution of 25% sodium methanolate (671 mg) was slowly added under cooling at 0°C. The reaction mixture was slowly warmed up to room temperature over 1 hour. After completion of the reaction, the reaction solution was diluted with water and extracted with ethyl acetate (EtOAc). The organic phases were combined, concentrated and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to afford 2-chloro-5-fluoro-4-methoxy-6-methylpyrimidine in quantitative yield.

References

[1] Patent: WO2009/131974, 2009, A1. Location in patent: Page/Page column 88
[2] Patent: WO2014/66132, 2014, A1. Location in patent: Page/Page column 16-17
[3] Patent: WO2012/138590, 2012, A1. Location in patent: Page/Page column 71-72
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 7, p. 3231 - 3248

2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE Suppliers

China 23 India 1 Global 24

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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1192479-35-8, 2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINERelated Search:

2-CHLORO-5-FLUORO-4-METHOXY-6-METHYLPYRIMIDINE

Pyrimidine, 2-chloro-5-fluoro-4-methoxy-6-methyl-

1192479-35-8