ChemicalBook > CAS DataBase List > INCB3344

INCB3344

Product Name
INCB3344
CAS No.
1262238-11-8
Chemical Name
INCB3344
Synonyms
INCB 3344;INCB-3344;CC chemokine receptor,INCB3344,CCR,Inhibitor,inhibit,INCB-3344,INCB 3344;rel-N-[2-[[(3R,4R)-1-[trans-4-(1,3-Benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide;Benzamide, N-[2-[[(3R,4R)-1-[trans-4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-, rel-
CBNumber
CB52624184
Molecular Formula
C29H34F3N3O6
Formula Weight
577.59
MOL File
1262238-11-8.mol
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INCB3344 Property

Boiling point:
736.3±60.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥25.9 mg/mL in DMSO; insoluble in H2O; ≥89.8 mg/mL in EtOH
form 
solid
pka
12.94±0.46(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28433
Product name
INCB 3344
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
28433
Product name
INCB 3344
Packaging
10mg
Price
$638
Updated
2024/03/01
Cayman Chemical
Product number
28433
Product name
INCB 3344
Packaging
5mg
Price
$343
Updated
2024/03/01
ChemScene
Product number
CS-0347
Product name
INCB3344
Purity
99.73%
Packaging
5mg
Price
$190
Updated
2021/12/16
AK Scientific
Product number
4832CR
Product name
CID10008367
Packaging
1mg
Price
$201
Updated
2021/12/16
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INCB3344 Chemical Properties,Usage,Production

Description

INCB 3344 is an antagonist of chemokine (C-C motif) receptor 2 (CCR2; IC50 = 10 nM in WEHI-274 murine monocytes). It is selective for CCR2 over a panel of G protein-coupled receptors, including CCR1 and CCR5, with IC50s values greater than 1 μM. INCB 3344 inhibits chemotaxis of WEHI-274 cells induced by chemokine (C-C motif) ligand 2 (CCL2; IC50 = 10 nM) and CCL2-induced phosphorylation of ERK in WEHI-274 cells. It inhibits monocyte influx in a mouse model of peritonitis induced by thioglycolate when administered at doses of 60 and 100 mg/kg. INCB 3344 (30, 50, and 100 mg/kg twice per day) decreases the expression of CCR2 mRNA in the ear and reduces ear swelling in a mouse model of delayed-type hypersensitivity reaction. It prevents increases in or reduces macrophage levels in the spinal cord when administered at a dose of 100 mg/kg per day beginning the day of immunization or seven days following immunization, respectively, in a mouse model of experimental autoimmune encephalomyelitis (EAE). It also reduces disease incidence and severity in the same model and reduces disease severity in a rat model of adjuvant-induced arthritis. INCB 3344 reduces macrophage infiltration to the kidney and improves renal function in a mouse model of polycystic kidney disease.

References

[1]. brodmerkel c m, huber r, covington m, et al. discovery and pharmacological characterization of a novel rodent-active ccr2 antagonist, incb3344[j]. the journal of immunology, 2005, 175(8): 5370-5378.

INCB3344 Preparation Products And Raw materials

Raw materials

Preparation Products

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INCB3344 Suppliers

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1262238-11-8, INCB3344Related Search:


  • INCB 3344;INCB-3344
  • rel-N-[2-[[(3R,4R)-1-[trans-4-(1,3-Benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
  • Benzamide, N-[2-[[(3R,4R)-1-[trans-4-(1,3-benzodioxol-5-yl)-4-hydroxycyclohexyl]-4-ethoxy-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-, rel-
  • CC chemokine receptor,INCB3344,CCR,Inhibitor,inhibit,INCB-3344,INCB 3344
  • 1262238-11-8
  • API