VTP-27999 (Hydrochloride)

Product Name: VTP-27999 (Hydrochloride)
CAS No.: 1264191-73-2
Chemical Name: VTP-27999 (Hydrochloride)
Synonyms: VTP-27999 HCl;VTP-27999 (Hydrochloride);VTP27999; VTP 27999;VTP27999 HYDROCHLORIDE; VTP 27999 HYDROCHLORIDE;methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate hydrochloride;N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamic acid methyl ester hydrochloride (1:1);Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, hydrochloride (1:1)
CBNumber: CB52624346
Molecular Formula: C26H42Cl2N4O5
Formula Weight: 561.55
MOL File: 1264191-73-2.mol

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VTP-27999 (Hydrochloride) Property

form: Powder
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0835
Product name: VTP-27999Hydrochloride
Purity: 98.10%
Packaging: 5mg
Price: $456
Updated: 2021/12/16

ChemScene

Product number: CS-0835
Product name: VTP-27999Hydrochloride
Purity: 98.10%
Packaging: 10mg
Price: $792
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611810
Product name: VTP-27999 hydrochloride
Packaging: 10mg
Price: $805.8
Updated: 2021/12/16

ChemScene

Product number: CS-0835
Product name: VTP-27999Hydrochloride
Purity: 98.10%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611810
Product name: VTP-27999 hydrochloride
Packaging: 50mg
Price: $1654.1
Updated: 2021/12/16

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VTP-27999 (Hydrochloride) Chemical Properties,Usage,Production

Description

VTP-27999 Hydrochloride is a potent inhibitor of renin with IC50 value of 0.3 nM for human renin.

Uses

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin

target

human renin

References

[1] Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751
[2] New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082. DOI:10.1161/HYPERTENSIONAHA.111.00967
[3] Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25. DOI:10.1021/ci200605k

VTP-27999 (Hydrochloride) Preparation Products And Raw materials

Raw materials

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VTP-27999 (Hydrochloride) Suppliers

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1264191-73-2, VTP-27999 (Hydrochloride)Related Search:

VTP27999; VTP 27999;VTP27999 HYDROCHLORIDE; VTP 27999 HYDROCHLORIDE

Carbamic acid, N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester, hydrochloride (1:1)

VTP-27999 HCl

VTP-27999 (Hydrochloride)

N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamic acid methyl ester hydrochloride (1:1)

methyl 2-((R)-(3-chlorophenyl)((R)-1-((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate hydrochloride

1264191-73-2

C26H41ClN4O5HCl

C26H41ClN4O5ClH