2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-

Product Name: 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
CAS No.: 852391-19-6
Chemical Name: 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
Synonyms: Necrostatin 2;Necroptotic Inhibitor;Necrostatin 2 R-isomer;MTH-DL-TRYPTOPHAN; NECROPTOTIC INHIBITOR;(5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione;2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
CBNumber: CB52626148
Molecular Formula: C13H12ClN3O2
Formula Weight: 277.71
MOL File: 852391-19-6.mol

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2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Property

Density: 1.450±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 8.48±0.70(Predicted)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11657
Product name: Necrostatin-2
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 11657
Product name: Necrostatin-2
Purity: ≥98%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 11657
Product name: Necrostatin-2
Purity: ≥98%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

ApexBio Technology

Product number: A3652
Product name: Necrostatin2
Packaging: 5mg
Price: $273
Updated: 2021/12/16

AK Scientific

Product number: 6577CS
Product name: (5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione
Packaging: 10mg
Price: $345
Updated: 2021/12/16

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2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Chemical Properties,Usage,Production

Biological Activity

necrostatin 2 (nec-2) is a novel and potent necroptosis inhibitor with ec50 of 50 nm. it is an analog of necrostatin 1 (nec-1).necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.nec-2 is efficacious in an animal model of ischemic stroke. many necroptosis inhibitor derivatives are designed for researchers. there is limited record for nec-2, but some reports are related with other necrostatins. nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase rip1 in vitro.

target

RIPK2

References

[1]. teng x, keys h, jeevanandam a, structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. bioorg med chem lett. 2007 dec 15;17(24):6836-40.

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Suppliers

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852391-19-6, 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-Related Search:

2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-

Necrostatin 2

(5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione

MTH-DL-TRYPTOPHAN; NECROPTOTIC INHIBITOR

Necroptotic Inhibitor

Necrostatin 2 R-isomer

852391-19-6