ChemicalBook > CAS DataBase List > ATB 346

ATB 346

Product Name: ATB 346
CAS No.: 1226895-20-0
Chemical Name: ATB 346
Synonyms: ATB 346;ABT-346;CS-1282;Otenaproxesul;ATB-346, >=98%;ATB346;ATB 346;ATB 346 ，S6615;ATB 346,1226895-20-0;Otenaproxesul, 10 mM in DMSO;4-CARBAMOTHIOYLPHENYL 2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOATE
CBNumber: CB52627347
Molecular Formula: C21H19NO3S
Formula Weight: 365.45
MOL File: 1226895-20-0.mol

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ATB 346 Property

Boiling point:: 561.4±60.0 °C(Predicted)
Density: 1.261±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥18.27 mg/mL in DMSO
form: solid
pka: 12.37±0.29(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16234
Product name: ATB-346
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 16234
Product name: ATB-346
Purity: ≥98%
Packaging: 50mg
Price: $468
Updated: 2024/03/01

Cayman Chemical

Product number: 16234
Product name: ATB-346
Purity: ≥98%
Packaging: 1mg
Price: $55
Updated: 2021/12/16

Cayman Chemical

Product number: 16234
Product name: ATB-346
Purity: ≥98%
Packaging: 10mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 16234
Product name: ATB-346
Purity: ≥98%
Packaging: 25mg
Price: $288
Updated: 2024/03/01

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ATB 346 Chemical Properties,Usage,Production

Description

ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H₂S) and a derivative of naproxen . It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 μM. ATB-346 decreases prostaglandin E₂ (PGE₂) production in inflammatory exudates, reduces paw edema, and increases plasma levels of sulfide in a mouse model of zymosan-induced arthritis. It reduces the size of acetic acid-induced gastric ulcers in mice when administered at a dose of 60 μmol/kg. ATB-346 (30 μmol/kg) improves motor function in a mouse model of spinal cord injury.

Uses

Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities[1][4].

in vivo

Otenaproxesul exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity^[1].
Otenaproxesul (orally, 43 μmol/kg) inhibits growth of melanoma tumors in vivo and reduce plasma levels of melanoma-associated chemokines^[2].
Otenaproxesul (orally, 16 mg/kg) results in significant inhibition of bone defect and other histological characteristics (such as flatness of the gingival epithelium, chronic inflammatory cell infiltration and loss of connective tissue in the gingival papillae). Otenaproxesul inhibits the increase of gingival IL-1β and IL-6 secondary to periodontitis, but IL-10 is unaffected^[3].

Animal Model:	Male, Wistar rats (200-225 g)^[1].
Dosage:	30, 60, 120 and 2740 μmol/kg.
Administration:	Orally once.
Result:	Inhibited PGE2 levels. Suppressed TXB2 synthesis.

Animal Model:	Male, Wistar rats (200-225 g)^[1].
Dosage:	4 μmol/kg.
Administration:	Orally twice daily, on days 7 to 21.
Result:	Significantly reduced paw oedema at days 14 and 21 (*P < 0.05 vs. the vehicle-treated group). Caused markedly less gastric damage at all doses tested than naproxen.

IC 50

COX-1; COX-2

References

[1] wallace j l, caliendo g, santagada v, et al. markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (atb-346). british journal of pharmacology, 2010, 159(6): 1236-1246.

ATB 346 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATB 346 Suppliers

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View Lastest Price from ATB 346 manufacturers

Career Henan Chemical Co

Product: ATB 346 1226895-20-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

1226895-20-0, ATB 346Related Search:

AST 487

ATB 346

4-CARBAMOTHIOYLPHENYL 2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOATE

ABT-346

6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester

6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester ATB 346

ATB 346 6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester

ATB-346, >=98%

ATB 346,1226895-20-0

ATB346;ATB 346

CS-1282

2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, 4-(aminothioxomethyl)phenyl ester

Otenaproxesul

Otenaproxesul, 10 mM in DMSO

ATB 346 ，S6615

1226895-20-0

Inhibitors