ChemicalBook > CAS DataBase List > ATB 346

ATB 346

Product Name
ATB 346
CAS No.
1226895-20-0
Chemical Name
ATB 346
Synonyms
ATB 346;ABT-346;CS-1282;Otenaproxesul;ATB-346, >=98%;ATB346;ATB 346;ATB 346,1226895-20-0;4-CARBAMOTHIOYLPHENYL 2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOATE;2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, 4-(aminothioxomethyl)phenyl ester;6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester
CBNumber
CB52627347
Molecular Formula
C21H19NO3S
Formula Weight
365.45
MOL File
1226895-20-0.mol
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ATB 346 Property

Boiling point:
561.4±60.0 °C(Predicted)
Density 
1.261±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥18.27 mg/mL in DMSO
form 
solid
pka
12.37±0.29(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16234
Product name
ATB-346
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
16234
Product name
ATB-346
Purity
≥98%
Packaging
50mg
Price
$468
Updated
2024/03/01
Cayman Chemical
Product number
16234
Product name
ATB-346
Purity
≥98%
Packaging
1mg
Price
$55
Updated
2021/12/16
Cayman Chemical
Product number
16234
Product name
ATB-346
Purity
≥98%
Packaging
10mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
16234
Product name
ATB-346
Purity
≥98%
Packaging
25mg
Price
$288
Updated
2024/03/01
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ATB 346 Chemical Properties,Usage,Production

Description

ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen . It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 μM. ATB-346 decreases prostaglandin E2 (PGE2) production in inflammatory exudates, reduces paw edema, and increases plasma levels of sulfide in a mouse model of zymosan-induced arthritis. It reduces the size of acetic acid-induced gastric ulcers in mice when administered at a dose of 60 μmol/kg. ATB-346 (30 μmol/kg) improves motor function in a mouse model of spinal cord injury.

References

[1] wallace j l, caliendo g, santagada v, et al. markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (atb-346). british journal of pharmacology, 2010, 159(6): 1236-1246.

ATB 346 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATB 346 Suppliers

China 72 India 1 The Netherlands 1 United Kingdom 1 United States 14 Global 89
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View Lastest Price from ATB 346 manufacturers

Career Henan Chemical Co
Product
ATB 346 1226895-20-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

1226895-20-0, ATB 346Related Search:

AST 487

  • ATB 346
  • 4-CARBAMOTHIOYLPHENYL 2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOATE
  • ABT-346
  • 6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester
  • 6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester ATB 346
  • ATB 346 6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester
  • ATB-346, >=98%
  • ATB 346,1226895-20-0
  • ATB346;ATB 346
  • CS-1282
  • 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, 4-(aminothioxomethyl)phenyl ester
  • Otenaproxesul
  • 1226895-20-0
  • Inhibitors