ChemicalBook > CAS DataBase List > Vipadenant
Vipadenant
Description References- Product Name
- Vipadenant
- CAS No.
- 442908-10-3
- Chemical Name
- Vipadenant
- Synonyms
- V 2006;CS-2294;BIIB 014;CEB 4520;VER 11135;Vipadenant;VER-ADO 49;VER-A 00-11;VER-A 00049;BIIB-014, CEB-4520
- CBNumber
- CB52627600
- Molecular Formula
- C16H15N7O
- Formula Weight
- 321.34
- MOL File
- 442908-10-3.mol
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Vipadenant Property
- Melting point:
- 245.3-246.1 °C
- Boiling point:
- 668.5±65.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:37.0(Max Conc. mg/mL);115.14(Max Conc. mM)
- form
- A crystalline solid
- pka
- 4.27±0.30(Predicted)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 20239
- Product name
- Vipadenant
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20239
- Product name
- Vipadenant
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $121
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20239
- Product name
- Vipadenant
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $469
- Updated
- 2024/03/01
TRC
- Product number
- V670808
- Product name
- Vipadenant
- Packaging
- 50mg
- Price
- $1440
- Updated
- 2021/12/16
TRC
- Product number
- V670808
- Product name
- Vipadenant
- Packaging
- 5mg
- Price
- $255
- Updated
- 2021/12/16
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Vipadenant Chemical Properties,Usage,Production
Description
Vipadenant (also known as BIIB014) is a potent, selective oral adenosine A2A receptor antagonist under development for the treatment of Parkinson’s disease. It has successfully completed phase I clinical studies. It might also be a potential adjunctive therapy reagent for cancer treatment. It was found that it has certain potentials to disrupt an immunosuppressive mechanism of tumour protection, generating improved efficacy for immunotherapies of certain cancers when used in combination with other drugs.
References
http://www.medkoo.com/products/8047
Shook, B. C., and P. F. Jackson. "Adenosine A(2A) Receptor Antagonists and Parkinson's Disease. " Acs Chemical Neuroscience2.10(2011):555-67.
Brooks, D. J., et al. "An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers." Clinical Neuropharmacology 33.2(2010):55.
http://www.vernalis.com/nce-pipeline/oncology/v2006
Uses
Vipadenant is a potent, selective and orally available adenosine A2A receptor antagonist under development for for Parkinson''s disease. Vipadenant demonstrates strong oral activity in commonly used models of Parkinson''s disease. Vipadenant has shown excellent preclinical pharmacokinetics and has successfully completed phase I clinical studies.
Vipadenant Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Vipadenant manufacturers
Career Henan Chemical Co
- Product
- Vipadenant 442908-10-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01