CBB 1007

Product Name: CBB 1007
CAS No.: 1379573-92-8
Chemical Name: CBB 1007
Synonyms: CS-1737;CBB 1007;SCHEMBL16273312;CBB-1007,CBB1007;Benzoic acid, 3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-[[4-(aminoiminomethyl)-1-piperazinyl]methyl]-, methyl ester
CBNumber: CB52627675
Molecular Formula: C27H34N8O4
Formula Weight: 534.61
MOL File: 1379573-92-8.mol

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CBB 1007 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B1263
Product name: CBB1007
Packaging: 5mg
Price: $366
Updated: 2021/12/16

ApexBio Technology

Product number: B1263
Product name: CBB1007
Packaging: 10mg
Price: $557
Updated: 2021/12/16

ApexBio Technology

Product number: B1263
Product name: CBB1007
Packaging: 2mg
Price: $245
Updated: 2021/12/16

ApexBio Technology

Product number: B1263
Product name: CBB1007
Packaging: 50mg
Price: $1319
Updated: 2021/12/16

Crysdot

Product number: CD31003691
Product name: CBB1007
Purity: 98+%
Packaging: 5mg
Price: $163
Updated: 2021/12/16

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CBB 1007 Chemical Properties,Usage,Production

Biological Activity

cbb1007 is an inhibitor of histone demethylase lsd1with ic50 values of 5.27μm [1].lsd1 is a member of the fad-dependent amine oxidase family. it converts di-methylated h3k4 to mono- and un-methylated h3k4 and suppresses gene expression. as an inhibitor of lsd1, cbb1007 is developed to understand the function of the enzyme. in the in vitro assay, cbb1007 shows highly potent inhibitory activity with ic50 value of 5.27μm. it is specific against lsd1 and has no effect on other histone demethylases including lsd2 and jarid1a. in the mouse f9 embryonic teratocarcinoma cells, cbb1007 cause a reproducible increase of mono- and di-methylated h3k4 with ic50 value of 1μm-5μm. it also activates the expression of chrm4 and scn3a which are the target genes of lsd1. the inhibition of lsd1 results in the growth inhibition of these cells. furthermore, cbb1007 is found to inhibit the proliferation of other pluripotent cancer cells as well as the embryonic stem cells that express the stem cell markers oct4 and sox2 [1].

References

[1] wang j, lu f, ren q, et al. novel histone demethylase lsd1 inhibitors selectively target cancer cells with pluripotent stem cell properties. cancer research, 2011, 71(23): 7238-7249.

CBB 1007 Preparation Products And Raw materials

Raw materials

Preparation Products

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CBB 1007 Suppliers

China 20 United States 8 Global 28

LETOPHARM LIMITED

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1379573-92-8, CBB 1007Related Search:

CBB 1007

CS-1737

SCHEMBL16273312

Benzoic acid, 3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-[[4-(aminoiminomethyl)-1-piperazinyl]methyl]-, methyl ester

CBB-1007,CBB1007

1379573-92-8

C27H34N8O4