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TBPB

Product Name: TBPB
CAS No.: 634616-95-8
Chemical Name: TBPB
Synonyms: TBPB(1%EA);TBPB, 10 mM in DMSO;1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one;1-(1'-(2-Methylbenzyl)-[1,4'-bipiperidin]-4-yl)-1H-benzo[d]imidazol-2(3H)-one;1,3-Dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one;2H-BenziMidazol-2-one, 1,3-dihydro-1-[1'-[(2-Methylphenyl)Methyl][1,4'-bipiperidin]-4-yl]-;1-{1'-[(2-methylphenyl)methyl]-[1,4'-bipiperidin]-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
CBNumber: CB52628445
Molecular Formula: C25H32N4O
Formula Weight: 404.55
MOL File: 634616-95-8.mol

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TBPB Property

Density: 1.193±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL (clear solution; warmed)
pka: 12.04±0.30(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0453
Product name: TBPB
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $89.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0453
Product name: TBPB
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $436
Updated: 2022/05/15

Cayman Chemical

Product number: 22943
Product name: TBPB
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22943
Product name: TBPB
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 22943
Product name: TBPB
Packaging: 10mg
Price: $163
Updated: 2024/03/01

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TBPB Chemical Properties,Usage,Production

Uses

TBPB is an allosteric M1 muscarinic acetylcholine receptor activator that regulates amyloid processing and produces antipsychotic-like activity in rats.

Biological Activity

TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimerμs. M1 agonists are being studied as potential therapeutic agents to tre at Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia.

in vivo

TBPB (60 mg/kg; subcutaneous injection; single dose; 2 h before sepsis induction) significantly reduces mortality in E. coli-induced murine sepsis model, with 20% and 23.2% decreases in 4- and 24-hour mortality, while inhibiting TNF-α, IL-1β, and IL-6 levels^[3].

Animal Model:	Random-bred albino mice (male/female, 18-22 g) with E. coli-induced sepsis^[3]
Dosage:	60 mg/kg
Administration:	Subcutaneous injection, single dose, 2 hours prior to sepsis induction
Result:	Reduced 4-hour mortality by 20% and 24-hour mortality by 23.2% compared to vehicle control. Significantly decreased blood concentrations of TNF-α, IL-1β, and IL-6 by 2.8-, 2.2-, and 7.3-fold respectively at 4 hours post-sepsis induction.

IC 50

mAChR1: 289 nM (EC₅₀)

TBPB Preparation Products And Raw materials

Raw materials

Preparation Products

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TBPB Suppliers

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View Lastest Price from TBPB manufacturers

Career Henan Chemica Co

Product: TBPB 634616-95-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: MIn98%HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-29

634616-95-8, TBPBRelated Search:

2H-BenziMidazol-2-one, 1,3-dihydro-1-[1'-[(2-Methylphenyl)Methyl][1,4'-bipiperidin]-4-yl]-

1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

1,3-Dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one

TBPB(1%EA)

1-(1'-(2-Methylbenzyl)-[1,4'-bipiperidin]-4-yl)-1H-benzo[d]imidazol-2(3H)-one

1-{1'-[(2-methylphenyl)methyl]-[1,4'-bipiperidin]-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one

TBPB, 10 mM in DMSO

634616-95-8

Inhibitors