ChemicalBook > CAS DataBase List > N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine

Product Name: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine
CAS No.: 179552-74-0
Chemical Name: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine
Synonyms: Afatinib Impurity 137;Dacomitinib Intermediate 2;N-(3-chloro-2-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinamine;N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinam...;N - (3-Chloro-4-fluorophenyl) -7-methoxy-6-nitroquinoline-4-amine;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-;(3-chloro-4-fluoro-phenyl)-(7-methoxy-6-nitro-quinazolin-4-yl)-amine
CBNumber: CB52629972
Molecular Formula: C15H10ClFN4O3
Formula Weight: 348.72
MOL File: 179552-74-0.mol

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N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Property

Boiling point:: 515.5±50.0 °C(Predicted)
Density: 1.529±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 5.07±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C367560
Product name: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Packaging: 1g
Price: $160
Updated: 2021/12/16

TRC

Product number: C367560
Product name: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Packaging: 10g
Price: $1260
Updated: 2021/12/16

AK Scientific

Product number: 8006CZ
Product name: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Packaging: 5g
Price: $331
Updated: 2021/12/16

AK Scientific

Product number: 8006CZ
Product name: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Packaging: 10g
Price: $474
Updated: 2021/12/16

Chemenu

Product number: CM142805
Product name: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Purity: 97%
Packaging: 25g
Price: $542
Updated: 2021/12/16

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N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Chemical Properties,Usage,Production

Uses

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine is a useful synthetic intermediate in the synthesis of Afatinib (A355300); an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

Synthesis

67-56-1

162012-67-1

179552-74-0

General procedure: N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine (15 g, 44.56 mmol) was dissolved in methanol (150 mL) and 50% aqueous potassium hydroxide solution (5 g, 89 mmol) was added. The reaction mixture was stirred at room temperature and then heated to 70 °C and stirred continuously for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate. The organic layers were combined, washed with water and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to afford N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine (20 g, 96.7% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 10.16 (s, 1H), 9.21 (s, 1H), 8.67 (s, 1H), 8.15 (dd, J = 2.4,6.8 Hz, 1H), 7.79-7.81 (m, 1H), 7.48 (t, J = 7.2 Hz, 2H), 4.07 (s, 3H ).

References

[1] Patent: CN103987700, 2016, B. Location in patent: Paragraph 0182-0184
[2] Patent: US2014/161801, 2014, A1. Location in patent: Page/Page column 0079-0080
[3] Patent: WO2018/119441, 2018, A1. Location in patent: Paragraph 00618; 0619
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 7, p. 1495 - 1503
[5] Patent: CN106008480, 2016, A. Location in patent: Paragraph 0086; 0087; 0088; 0089

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine 179552-74-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Hebei Yanxi Chemical Co., Ltd.

Product: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine 179552-74-0
Price: US $50.00/KG
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Supply Ability: 100000
Release date: 2023-09-06

Nanjing Fred Technology Co., Ltd

Product: N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine 179552-74-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-22

179552-74-0, N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMineRelated Search:

Afatinib iMpurity 4-Hydroxy 4-Dedimethylamino Afatinib Afatinib-d6 Afatinib IMpurity H Afatinib Impurity 74 Afatinib impurity 40 Afatinib impurity 33 TRANS-4-AMINOCROTONIC ACID Afatinib Impurity L (Afatinib N-Oxide) Afatinib Impurity 22 Afatinib impurity 30 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Afatinib impurity 27 Afatinib impurity 34 Afatinib impurity 41 Afatinib Impurity I Afatinib-d4 Afatinib Impurity K

N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinamine

(3-chloro-4-fluoro-phenyl)-(7-methoxy-6-nitro-quinazolin-4-yl)-amine

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-

Afatinib Impurity 137

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinam...

N-(3-chloro-2-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

N - (3-Chloro-4-fluorophenyl) -7-methoxy-6-nitroquinoline-4-amine

Dacomitinib Intermediate 2

179552-74-0

C15H10ClFN4O3