2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one

Product Name: 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one
CAS No.: 15783-48-9
Chemical Name: 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one
Synonyms: 2,4-dichloro-5H-furo[3,4-d]pyrimidin-7-one;2,4-Dichlorofuro[3,4-d]pyrimidin-7(5H)-one;2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one;Furo[3,4-d]pyrimidin-7(5H)-one, 2,4-dichloro-
CBNumber: CB52631737
Molecular Formula: C6H2Cl2N2O2
Formula Weight: 205
MOL File: 15783-48-9.mol

More

Less

2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one Property

Boiling point:: 464.0±45.0 °C(Predicted)
Density: 1.760±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -5.44±0.20(Predicted)
Appearance: Off-white to yellow Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: D434565
Product name: 2,4-Dichlorofuro[3,4-d]pyrimidin-7(5H)-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D434565
Product name: 2,4-Dichlorofuro[3,4-d]pyrimidin-7(5H)-one
Packaging: 50mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD141332
Product name: 2,4-Dichlorofuro[3,4-d]pyrimidin-7(5H)-one
Packaging: 100mg
Price: $93
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD141332
Product name: 2,4-Dichlorofuro[3,4-d]pyrimidin-7(5H)-one
Packaging: 50mg
Price: $53
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD141332
Product name: 2,4-Dichlorofuro[3,4-d]pyrimidin-7(5H)-one
Packaging: 500mg
Price: $325
Updated: 2021/12/16

More

Less

2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one Chemical Properties,Usage,Production

Synthesis

4156-75-6

15783-48-9

Step 2-Synthesis of 2,4-dichlorofuro[3,4-d]pyrimidin-7(5H)-one (fq): to a suspension of 5-hydroxymethyl orotate lactone (fp) (550 mg, 3.3 mmol) in dichloromethane (2.5 mL) was added drop-wise triethylamine (TEA) (0.91 mL, 6.5 mmol), followed by phosphorus oxychloride (POCl3) ( 4.5 mL, 48 mmol). The reaction mixture was stirred at 90 °C overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was carefully poured into ice water and extracted with dichloromethane (3×). The organic phases were combined, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give 510 mg (76% yield) of the target product (fq) as a brown solid. The product could be used in subsequent reactions without further purification; LC-MS: m/z = 205 ([M+H]+).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2565 - 2571
[2] Patent: US2010/331305, 2010, A1. Location in patent: Page/Page column 75
[3] Patent: US2011/21515, 2011, A1. Location in patent: Page/Page column 10
[4] Patent: WO2012/99581, 2012, A1. Location in patent: Page/Page column 21

2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one Suppliers

China 32 India 1 United Kingdom 1 United States 4 Global 38

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Boyners Pharm-Tech Co., Ltd.

Tel: 13817873692
Fax: 021-31329586
Email: mkt@boynerspharm.com
Country: China
ProdList: 1707
Advantage: 55

Shanghai TuZhi Chemical Co., Ltd.

Tel: 19542790274
Fax: QQ1456295541
Email: 2119559397@qq.com
Country: China
ProdList: 754
Advantage: 50

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Jiaxing Nova Chemical Co., Ltd.

Tel: 021-20921617 18957373295
Fax: 021-20921617
Email: 2240425080@qq.com
Country: China
ProdList: 891
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

15783-48-9, 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-oneRelated Search:

2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one

2,4-Dichlorofuro[3,4-d]pyrimidin-7(5H)-one

2,4-dichloro-5H-furo[3,4-d]pyrimidin-7-one

Furo[3,4-d]pyrimidin-7(5H)-one, 2,4-dichloro-

15783-48-9