5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

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5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

Product Name: 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
CAS No.: 881674-56-2
Chemical Name: 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Synonyms: 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde;Vonorazan;VONOPRAZAN IST-1;5-(2-FL;e-3-carbaL;)-1H-pyrroL;Vonoprazan-1;Vonoprazan-023
CBNumber: CB52638918
Molecular Formula: C11H8FNO
Formula Weight: 189.19
MOL File: 881674-56-2.mol

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5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Property

Melting point:: 133 °C
Boiling point:: 370.6±32.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 14.77±0.50(Predicted)
color: Light Brown to Brown
Stability:: Hygroscopic
InChI: InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H
InChIKey: MQULPEUCGKEHEG-UHFFFAOYSA-N
SMILES: N1C(C2=CC=CC=C2F)=CC(C=O)=C1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F1074
Product name: 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $98
Updated: 2024/03/01

TCI Chemical

Product number: F1074
Product name: 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $295
Updated: 2024/03/01

TRC

Product number: F489655
Product name: 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Packaging: 1g
Price: $105
Updated: 2021/12/16

TRC

Product number: F489655
Product name: 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Packaging: 250mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-W004473
Product name: 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
Purity: 99.96%
Packaging: 10g
Price: $67
Updated: 2021/12/16

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5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties,Usage,Production

Description

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is an ether. It can be used to prepare vonoprazan fumarate, which is a potent orally active potassium-competitive acid blocker (P-CAB) with antisecretory activity. It is used in the study of acid-related diseases.

Chemical Properties

Light orange to Yellow to Green powder to crystal.

Uses

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).

Application

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.

Preparation

Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.

Definition

The 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde is an important intermediate of Voranolan fumarate, a competitive potassium ion acid blocker. Voranolan fumarate treats gastric ulcers, duodenal ulcers, reflux esophagitis, etc. 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde can be synthesized in one pot using 2-(2-fluorobenzoyl)malononitrile as raw material.

Hazard

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde has acute toxin effects and is a skin and eye irritant.

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Suppliers

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View Lastest Price from 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde manufacturers

Hebei Dangtong Import and export Co LTD

Product: 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2
Price: US $1110.00-1000.00/kilograms
Min. Order: 1kilograms
Purity: 99.95%
Supply Ability: 100tons
Release date: 2023-02-14

hebei hongtan Biotechnology Co., Ltd

Product: 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2
Price: US $50.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 1000
Release date: 2024-03-20

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde 881674-56-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2022-02-17

881674-56-2, 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehydeRelated Search:

5-chloropyridine-3-sulfonyl chloride Vonoprazan Fumarate impurity 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester 1H-Pyrrole-3-methanamine, 1-[(1,4-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 1H-Pyrrole-3-methanamine, 1-[(1,6-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile Vonoprazan fumarate 1-(2-chloro-5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine Vonoprazan 3-N,N-dimethylsulfamoylpyridine 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 1-methylpyridin-1-ium-4-sulfonate 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Ezetimibe (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol

1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-

5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1H-pyrrole-3-carbal...

5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde

1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-

TAK438 Impurity 54

1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde

TAK-438( Vonoprazan fumarate) intermediate 3

5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde

1-[(2S) -2-pyrrolidinecarbonyl] -pyrrolidine

TAK438 Intermediate

Vonoprazan-1

5-(2-Fluorophenyl)pyrrole-3-carbaldehyde

Vonoprazan-023

5-(2-FL

e-3-carbaL

)-1H-pyrroL

VONOPRAZAN IST-1

5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehy

5 - (2-fluorophenyl) - 1h-pyrrole-3-formaldehyde

Vonorazan

5-(2-Fluorophenyl)-1H-pyrrol-3-carbaldehyde

Vonolazan impurity 1

TAK438 Impurity 54 CRS

5-(2-fluorophenyl)-1H-

881674-56-2

881647-56-2

Vonoprazan

Pharmaceutical Intermediates

881674-56-2