ChemicalBook > CAS DataBase List > 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

Product Name
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
CAS No.
881674-56-2
Chemical Name
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Synonyms
5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde;Vonorazan;VONOPRAZAN IST-1;5-(2-FL;e-3-carbaL;)-1H-pyrroL;Vonoprazan-1;Vonoprazan-023
CBNumber
CB52638918
Molecular Formula
C11H8FNO
Formula Weight
189.19
MOL File
881674-56-2.mol
More
Less

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Property

Melting point:
133 °C
Boiling point:
370.6±32.0 °C(Predicted)
Density 
1.270±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
14.77±0.50(Predicted)
color 
Light Brown to Brown
Stability:
Hygroscopic
InChI
InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H
InChIKey
MQULPEUCGKEHEG-UHFFFAOYSA-N
SMILES
N1C(C2=CC=CC=C2F)=CC(C=O)=C1
More
Less

Safety

HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
F1074
Product name
5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
Purity
>98.0%(GC)
Packaging
1g
Price
$98
Updated
2024/03/01
TCI Chemical
Product number
F1074
Product name
5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
Purity
>98.0%(GC)
Packaging
5g
Price
$295
Updated
2024/03/01
TRC
Product number
F489655
Product name
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Packaging
250mg
Price
$50
Updated
2021/12/16
TRC
Product number
F489655
Product name
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Packaging
1g
Price
$105
Updated
2021/12/16
ChemScene
Product number
CS-W004473
Product name
5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
Purity
99.96%
Packaging
10g
Price
$67
Updated
2021/12/16
More
Less

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties,Usage,Production

Description

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is an ether. It can be used to prepare vonoprazan fumarate, which is a potent orally active potassium-competitive acid blocker (P-CAB) with antisecretory activity. It is used in the study of acid-related diseases.

Chemical Properties

Light orange to Yellow to Green powder to crystal.

Uses

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).

Application

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.

Preparation

Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.

Definition

The 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde is an important intermediate of Voranolan fumarate, a competitive potassium ion acid blocker. Voranolan fumarate treats gastric ulcers, duodenal ulcers, reflux esophagitis, etc. 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde can be synthesized in one pot using 2-(2-fluorobenzoyl)malononitrile as raw material.

Hazard

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde has acute toxin effects and is a skin and eye irritant.

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Suppliers

Americas 1 Belgium 1 Canada 2 China 448 Europe 1 Germany 3 India 16 Japan 2 Switzerland 1 United Kingdom 3 United States 15 Global 493
Ningbo Zhenlei Chemical Co.,ltd.
Tel
0576-88808091 13958565781
Fax
+0576-88203603
Email
shuang.lin@zhenleichem.com
Country
China
ProdList
89
Advantage
58
Cangzhou Weizhidamei Pharmaceutical Co., Ltd.
Tel
13426038769 13426038769
Fax
0317-5486999
Email
askmryu@163.com
Country
China
ProdList
60
Advantage
58
Shandong Xuande Pharmaceutical Technology Co. LTD
Tel
18866895588
Fax
0531-82777287
Email
dingjiaying@shiningpharm.com
Country
China
ProdList
95
Advantage
55
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd
Tel
010-53679529 13801208576
Fax
010-64215766
Email
sales.2@chinazhongshuo.com
Country
China
ProdList
99
Advantage
65
Shandong Chuangye Pharmaceutical Technology Co., Ltd.
Tel
13325129676
Email
3610186177@qq.com
Country
China
ProdList
22
Advantage
58
Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd.
Tel
0531-58897130 15508676053
Email
drug_impurity@sdcclh.com
Country
China
ProdList
2007
Advantage
58
Enantiotech Corporation Ltd
Tel
760-85282375 13212762451
Email
marketing@enantiotech.net
Country
China
ProdList
184
Advantage
55
Zhuhai Hairuide Bioscience and Technology Co., Ltd
Tel
0756-7789199 13326687259
Email
sales@zhhairuide.com
Country
China
ProdList
106
Advantage
58
Jinan Sanyuan Chemical Co. LTD
Tel
0531-58582194 13335164090
Fax
0531-58585914
Email
1660423085@qq.com
Country
China
ProdList
405
Advantage
58
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
832
Advantage
65
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Jiangsu Vcare PharmaTech Co., Ltd.
Tel
13327700685
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
310
Advantage
61
Jinan Chenghui Shuangda biological Co., LTD
Tel
0531-58897003 15550412551
Fax
0531-58897003
Email
market@jnchsd.com
Country
China
ProdList
211
Advantage
62
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2871
Advantage
58
Jinan Bond Chemical Technology Co., Ltd.
Tel
86-531-88280989
Fax
86-531-88280989
Email
mymail1996@126.com
Country
China
ProdList
256
Advantage
55
Shanghai SynFarm Pharmaceutical Technology Co., Ltd.
Tel
021-50793966 18917198199
Fax
+86-21-50793967
Email
info@synfarm.com
Country
China
ProdList
280
Advantage
58
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9459
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
Country
China
ProdList
4991
Advantage
58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
Tel
021-34666753 13311639313
Fax
+86-21-34979012
Email
info@shyrchem.com
Country
China
ProdList
571
Advantage
55
Emei shan Hongsheng Pharmaceutical Co., LTD
Tel
0833-6186278
Fax
0833-5590359
Email
sales@hongshengpharm.com
Country
China
ProdList
109
Advantage
60
EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
Email
sales@enlipharma.com
Country
China
ProdList
1874
Advantage
55
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
028-85122536 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
2000
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9895
Advantage
55
Ningbo Taikang Chemical Co., Ltd.
Tel
0574-87365517 18074210286
Fax
87367735
Email
sales@taikangchem.com
Country
China
ProdList
303
Advantage
58
Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
965
Advantage
58
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-18601685-898 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2769
Advantage
60
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
2353
Advantage
62
Zhengzhou Topcare Pharmaceutical Co.,Ltd.
Tel
0371-60942985
Fax
0371-60942986,qq1994339443
Country
China
ProdList
54
Advantage
58
Jinan XuanDe Chemical Co., Ltd.
Tel
0531-88803958; 18866891188
Fax
0531-82777287
Email
zhaojiangxia@shiningpharm.com
Country
China
ProdList
275
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5875
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10276
Advantage
55
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653715
Email
xingui2022@126.com
Country
China
ProdList
10021
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Shanghai AECOM Biotechnology Co. , Ltd.
Tel
021-021-20956531 18116226605
Fax
021-20956532
Email
sui@neosunpharm.com
Country
China
ProdList
350
Advantage
55
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4767
Advantage
60
Lihe Wuhan New Chemical Materials Co., Ltd.
Tel
027-88395709
Fax
027-88391805
Country
China
ProdList
429
Advantage
50
Beijing Xinsavi Chemical Technology Co., Ltd.
Tel
010-56218822 13717722232
Fax
010-56218800
Email
xinsavichem@163.com
Country
China
ProdList
3201
Advantage
56
Beijing Holiyang Chemical Co. Ltd.
Tel
13718199399
Fax
QQ : 206661479
Email
holiyangchem@163.com
Country
China
ProdList
3381
Advantage
56
Shanghai YouPeng Chemical Co. Ltd.
Tel
021-69005955 13701776567
Fax
021-69005775
Email
youpengchem@163.com
Country
China
ProdList
4293
Advantage
56
Sichuan Hainuowei Technology Co. Ltd.
Tel
13708085536
Fax
QQ : 121102042
Email
hanovichem@163.com
Country
China
ProdList
3383
Advantage
56
Shanghai TongYuan Chemical Co., Ltd.
Tel
021-021-69182866 13701855675
Fax
021-69182022
Email
tongyuanchem@126.com
Country
China
ProdList
4321
Advantage
58
More
Less

View Lastest Price from 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2
Price
US $0.00/Kg/Bag
Min. Order
10g
Purity
99%min
Supply Ability
10kg
Release date
2022-01-10
hebei hongtan Biotechnology Co., Ltd
Product
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2
Price
US $50.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
1000
Release date
2024-03-20
Shaanxi Dideu New Materials Co. Ltd
Product
5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde 881674-56-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-14

881674-56-2, 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehydeRelated Search:

5-chloropyridine-3-sulfonyl chloride Vonoprazan Fumarate impurity 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester 1H-Pyrrole-3-methanamine, 1-[(1,4-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 1H-Pyrrole-3-methanamine, 1-[(1,6-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl- 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile Vonoprazan fumarate 1-(2-chloro-5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine Vonoprazan 3-N,N-dimethylsulfamoylpyridine 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 1-methylpyridin-1-ium-4-sulfonate 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde Ezetimibe (4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol

  • 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-
  • 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
  • 5-(2-Fluorophenyl)-1H-pyrrole-3-carbal...
  • 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde
  • 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-
  • TAK438 Impurity 54
  • 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
  • TAK-438( Vonoprazan fumarate) intermediate 3
  • 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
  • 1-[(2S) -2-pyrrolidinecarbonyl] -pyrrolidine
  • TAK438 Intermediate
  • Vonoprazan-1
  • 5-(2-Fluorophenyl)pyrrole-3-carbaldehyde
  • Vonoprazan-023
  • 5-(2-FL
  • e-3-carbaL
  • )-1H-pyrroL
  • VONOPRAZAN IST-1
  • 5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehy
  • 5 - (2-fluorophenyl) - 1h-pyrrole-3-formaldehyde
  • Vonorazan
  • 5-(2-Fluorophenyl)-1H-pyrrol-3-carbaldehyde
  • Vonolazan impurity 1
  • TAK438 Impurity 54 CRS
  • 5-(2-fluorophenyl)-1H-
  • Novorazan Impurity 01
  • 5- (2-Fluorophenyl) -1H-pyrrol-3-carboxaldehyde
  • 881674-56-2
  • 881647-56-2
  • 81674-56-2
  • Vonoprazan
  • Pharmaceutical Intermediates
  • 881674-56-2