3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

Product Name: 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
CAS No.: 1233533-04-4
Chemical Name: 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
Synonyms: CS-2453;kbNB142-70, >98%;kb NB 142-70, 10 mM in DMSO;kb-NB142-70, protein kinase D inhibitor;3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one;9-Hydroxy-3,4-dihydrobenzo[4,5]thieno[2,3-f][1,4]thiazepin-5(2H)-one;[1]Benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one, 3,4-dihydro-9-hydroxy-;inhibit,kb NB 142-70,Inhibitor,kb NB 14270,PKD,Protein kinase D,kb NB 142 70;kb-NB142-70 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one;4-Hydroxy-8,14-dithia-11-azatricyclo[7.5.0.0^{2,7}]tetradeca-1(9),2,4,6-tetraen-10-one
CBNumber: CB52640283
Molecular Formula: C11H9NO2S2
Formula Weight: 251.32
MOL File: 1233533-04-4.mol

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3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one Property

Melting point:: 235-238℃ (decomposition) (water dichloromethane )
Boiling point:: 601.9±55.0 °C(Predicted)
Density: 1.495±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 8.99±0.20(Predicted)
form: powder
color: white to beige
InChI: 1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)
InChIKey: DHUAGGSHTKPOHU-UHFFFAOYSA-N
SMILES: Oc1ccc2sc3C(=O)NCCSc3c2c1

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Safety

WGK Germany: 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0525
Product name: kb-NB142-70
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $159
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML0525
Product name: kb-NB142-70
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $626
Updated: 2026/03/19

Cayman Chemical

Product number: 18002
Product name: kb NB 142-70
Purity: ≥98%
Packaging: 5mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 18002
Product name: kb NB 142-70
Purity: ≥98%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 18002
Product name: kb NB 142-70
Purity: ≥98%
Packaging: 25mg
Price: $352
Updated: 2024/03/01

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3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one Chemical Properties,Usage,Production

Uses

kb NB 142-70 is a potent & selective protein kinase D inhibitor.

Biological Activity

kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC50 for inhibition of PKD1 = 28.3 nM vs. 182 nM for CID755673). kb-NB142-70 dose dependently inhibits proliferation of PC3 prostate cancer cell, and blocks migration of the prostate cancer lines PC3 and DU145.

IC 50

PKD1: 28.3 nM (IC₅₀); PKD3: 53.2 nM (IC₅₀); PKD2: 58.7 nM (IC₅₀)

storage

Store at RT

3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one Suppliers

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View Lastest Price from 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one manufacturers

Career Henan Chemical Co

Product: 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one 1233533-04-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

1233533-04-4, 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-oneRelated Search:

kb-NB142-70 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

CS-2453

kbNB142-70, >98%

[1]Benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one, 3,4-dihydro-9-hydroxy-

4-Hydroxy-8,14-dithia-11-azatricyclo[7.5.0.0^{2,7}]tetradeca-1(9),2,4,6-tetraen-10-one

inhibit,kb NB 142-70,Inhibitor,kb NB 14270,PKD,Protein kinase D,kb NB 142 70

9-Hydroxy-3,4-dihydrobenzo[4,5]thieno[2,3-f][1,4]thiazepin-5(2H)-one

kb-NB142-70, protein kinase D inhibitor

kb NB 142-70, 10 mM in DMSO

1233533-04-4

Inhibitors