5-Ethynyl-2,2'-bipyridine

Product Name: 5-Ethynyl-2,2'-bipyridine
CAS No.: 162318-34-5
Chemical Name: 5-Ethynyl-2,2'-bipyridine
Synonyms: 5-Ethynyl-2,2'-bipyridine;2,2'-Bipyridine, 5-ethynyl-;5-ethynyl-2-(2-pyridyl)pyridine;5-ethynyl-2-pyridin-2-ylpyridine;5-Ethynyl-2,2'-bipyridine - [E56412];5-Ethy5-Ethynyl-2,2'-bipyridinenyl-2,2'-bipyridine
CBNumber: CB52642595
Molecular Formula: C12H8N2
Formula Weight: 180.21
MOL File: 162318-34-5.mol

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5-Ethynyl-2,2'-bipyridine Property

Melting point:: 87-89 °C
Boiling point:: 312.4±32.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.74±0.22(Predicted)
Appearance: Light yellow to light brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0091677
Product name: 5-Ethynyl-2,2'-bipyridine
Packaging: 100mg
Price: $131
Updated: 2021/12/16

Synthonix

Product number: E56412
Product name: 5-Ethynyl-2,2'-bipyridine
Purity: 95+%
Packaging: 100mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0091677
Product name: 5-Ethynyl-2,2'-bipyridine
Packaging: 250mg
Price: $203
Updated: 2021/12/16

Synthonix

Product number: E56412
Product name: 5-Ethynyl-2,2'-bipyridine
Purity: 95+%
Packaging: 250mg
Price: $220
Updated: 2021/12/16

Activate Scientific

Product number: AS45729
Product name: 5-Ethynyl-2,2'-bipyridine
Purity: 95+%
Packaging: 250mg
Price: $252
Updated: 2021/12/16

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5-Ethynyl-2,2'-bipyridine Chemical Properties,Usage,Production

Synthesis

187026-84-2

162318-34-5

General procedure for the synthesis of 5-alkynyl-2,2'-bipyridines from 5-trimethylsilylethynyl-2,2'-bipyridines: 5-[(trimethylsilyl)ethynyl]-2,2'-bipyridine (0.360 g, 1.43 mmol) was dissolved in 30 mL of THF (pre-gassed with N2). Subsequently, a methanol (30 mL) solution of KOH (0.320 g, 5.72 mmol) was added. The reaction mixture was stirred at room temperature for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was purified by fast silica gel column chromatography using dichloromethane as eluent. The product yield was 95% (245 mg). Thin layer chromatography (TLC, SiO2) showed an Rf value of 0.45 (10% methanol/dichloromethane). Infrared spectroscopy (IR, KBr, cm-1 ) showed characteristic absorption peaks: 3298 (C≡CH), 3190 (C≡CH), 3049 (Ar-H), 3001 (Ar-H), 2964 (Ar-H), 2933 (Ar-H), 2096 (C≡C).1H NMR (400 MHz, CDCl3) δ 3.29 (s, 1H , C≡CH), 7.26-7.33 (m, 1H, PyH), 7.79-7.84 (m, 1H, PyH), 7.88-7.90 (m, 1H, PyH), 8.37-8.41 (m, 2H, PyH), 8.67-8.69 (m, 1H, PyH), 8.77 (m, 1H, PyH). Mass spectra (MS/EI) showed m/z 180 [M+, 100%], 153 [M+-NCH, 48%], 126 [M+-2(NCH), 9%].

References

[1] Chemical Communications, 2012, vol. 48, # 8, p. 1120 - 1122
[2] Chemical Communications, 2015, vol. 51, # 38, p. 8161 - 8164
[3] Chemistry - A European Journal, 2017, vol. 23, # 50, p. 12162 - 12170
[4] Inorganic Chemistry, 2018, vol. 57, # 7, p. 3602 - 3614
[5] Angewandte Chemie - International Edition, 2002, vol. 41, # 12, p. 2086 - 2089

5-Ethynyl-2,2'-bipyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Ethynyl-2,2'-bipyridine Suppliers

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162318-34-5, 5-Ethynyl-2,2'-bipyridineRelated Search:

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5-Ethynyl-2,2'-bipyridine

5-Ethy5-Ethynyl-2,2'-bipyridinenyl-2,2'-bipyridine

5-ethynyl-2-pyridin-2-ylpyridine

2,2'-Bipyridine, 5-ethynyl-

5-ethynyl-2-(2-pyridyl)pyridine

5-Ethynyl-2,2'-bipyridine - [E56412]

162318-34-5

162381-34-5