RPR-260243

Product Name: RPR-260243
CAS No.: 668463-35-2
Chemical Name: RPR-260243
Synonyms: 100866;CS-2094;RPR-260243;RPR 260243;RPR260243;(3R,4R)-4-[3-(6-Methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl];(3r,4r)-4-(3-(6-methoxyquinolin-4-yl)-3-oxopropyl)-1-(3-(2,3,5-trifluorophenyl)prop-2-yn-1-yl)piperidine-3-carboxylic acid;(3R,4R)-4-[3-(6-Methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid;3-Piperidinecarboxylic acid, 4-[3-(6-methoxy-4-quinolinyl)-3-oxopropyl]-1-[3-(2,3,5-trifluorophenyl)-2-propyn-1-yl]-, (3R,4R)-
CBNumber: CB52645127
Molecular Formula: C28H25F3N2O4
Formula Weight: 510.5
MOL File: 668463-35-2.mol

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RPR-260243 Property

Boiling point:: 668.0±55.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at 2-8°C
solubility: DMSO: 10 mg/mL (19.59 mM)
form: Solid
pka: 3.71±0.40(Predicted)
color: Light yellow to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4322
Product name: RPR-260243
Purity: 99.37%
Packaging: 5mg
Price: $264
Updated: 2021/12/16

ChemScene

Product number: CS-4322
Product name: RPR-260243
Purity: 99.37%
Packaging: 10mg
Price: $444
Updated: 2021/12/16

AK Scientific

Product number: SYN5262
Product name: RPR-260243
Packaging: 50mg
Price: $1405
Updated: 2021/12/16

ChemScene

Product number: CS-4322
Product name: RPR-260243
Purity: 99.37%
Packaging: 50mg
Price: $1440
Updated: 2021/12/16

Matrix Scientific

Product number: 120682
Product name: (3R,4R)-4-[3-(6-Methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylicacid
Purity: 97%
Packaging: 100mg
Price: $1792
Updated: 2021/12/16

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RPR-260243 Chemical Properties,Usage,Production

Uses

RPR-260243, a potent activator of human ether-a-go-go-related gene (hERG), slows deactivation and attenuates inactivation of hERG1 channels. RPR260243-modified HERG currents are inhibited by Dofetilide (IC50=58 nM). RPR260243 displays no activator-like effects on other voltage-dependent ion channels, including the closely related ERG3 K+ channel[1][2]. RPR-260243 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1] Wu W, et al. Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243. Mol Pharmacol. 2015;87(3):401-409. DOI:10.1124/mol.114.096693
[2] Kang J, et al. Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel. Mol Pharmacol. 2005;67(3):827-836. DOI:10.1124/mol.104.006577

RPR-260243 Preparation Products And Raw materials

Raw materials

Preparation Products

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RPR-260243 Suppliers

CHINA 24 India 1 United States 7 Global 32

MedChemexpress LLC

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668463-35-2, RPR-260243Related Search:

RPR-260243

(3R,4R)-4-[3-(6-Methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid

(3R,4R)-4-[3-(6-Methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]

100866

RPR 260243;RPR260243

CS-2094

3-Piperidinecarboxylic acid, 4-[3-(6-methoxy-4-quinolinyl)-3-oxopropyl]-1-[3-(2,3,5-trifluorophenyl)-2-propyn-1-yl]-, (3R,4R)-

(3r,4r)-4-(3-(6-methoxyquinolin-4-yl)-3-oxopropyl)-1-(3-(2,3,5-trifluorophenyl)prop-2-yn-1-yl)piperidine-3-carboxylic acid

668463-35-2

C28H25F3N2O4