ChemicalBook > CAS DataBase List > NVP-BVU 972

NVP-BVU 972

Product Name
NVP-BVU 972
CAS No.
1185763-69-2
Chemical Name
NVP-BVU 972
Synonyms
CS-529;NVP-BVU972;NVP-BVU 972;NVP-BVU972, >=98%;NVP-BVU 972 USP/EP/BP;NVP-BVU972;NVP-BVU 972;NVP-BVU972, 10 mM in DMSO;6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline;Quinoline, 6-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]-;6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline NVP-BVU972
CBNumber
CB52645147
Molecular Formula
C20H16N6
Formula Weight
340.38
MOL File
1185763-69-2.mol
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NVP-BVU 972 Property

Density 
1.35
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥17 mg/mL in DMSO; ≥25.15 mg/mL in EtOH
form 
solid
pka
4.92±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
N925800
Product name
NVP-BVU972
Packaging
50mg
Price
$1050
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
66487
Product name
NVP-BVU972
Packaging
5mg
Price
$750
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001410
Product name
BVU-972
Purity
95.00%
Packaging
1MG
Price
$876.65
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0001410
Product name
BVU-972
Purity
95.00%
Packaging
5G
Price
$1807.58
Updated
2021/12/16
ChemScene
Product number
CS-0967
Product name
NVP-BVU972
Purity
98.38%
Packaging
50mg
Price
$1020
Updated
2021/12/16
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NVP-BVU 972 Chemical Properties,Usage,Production

Uses

NVP-BVU972 exhibits strong inhibition towards MET kinase but displays low inhibition against other kinases including the most closely related kinase RON.

Biological Activity

nvp-bvu972 is a selective and potent inhibitor of c-met with ic50 of 14 nm. besides, nvp-bvu972 displays ic50 values more than 1000 nm in other kinases such as the most closely related kinase recepteur d'origine nantais (ron).c-met, also known as hepatocyte growth factor receptor, is a receptor tyrosine kinase that can be activated by hepatocyte growth factor/scatter factor (hgf/sf). it is a membrane protein which plays an essential role in embryonic development and wound healing.in the ebc-1, gtl-16, and mkn-45 human cancer cells, nvp-bvu972 potently inhibits the cell proliferation with ic50 values of 82, 66 and 32 nm, respectively. additionally, nvp-bvu972 treatment leads to the inhibition of the growth of the transformed mouse baf3 cells containing tpr-met kinase fusions with ic50 of 104 nm 1.in human sample, nvp-bvu972 treatment on cells expressing wild-type tpr-met resulted in a dose-dependent reduction in tpr-met phosphorylation. y1230h, d1228a, f1200i and l1195v mutations abrogate the tpr-met phosphorylation inhibition effect of nvp-bvu972 in baf3 tpr-met1.

target

Met

References

1. tiedt r, degenkolbe e, furet p, et al. a drug resistance screen using a selective met inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. cancer research. 2011;71(15):5255-5264.

NVP-BVU 972 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-BVU 972 Suppliers

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View Lastest Price from NVP-BVU 972 manufacturers

Career Henan Chemical Co
Product
NVP-BVU972 1185763-69-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1ton
Release date
2020-01-10

1185763-69-2, NVP-BVU 972Related Search:

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  • 6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline NVP-BVU972
  • NVP-BVU 972
  • NVP-BVU972
  • 6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline
  • NVP-BVU972, >=98%
  • NVP-BVU972;NVP-BVU 972
  • CS-529
  • Quinoline, 6-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]-
  • NVP-BVU 972 USP/EP/BP
  • NVP-BVU972, 10 mM in DMSO
  • 1185763-69-2
  • Inhibitors