ChemicalBook > CAS DataBase List > AG 7352 Hydrochloride

AG 7352 Hydrochloride

Product Name: AG 7352 Hydrochloride
CAS No.: 175519-16-1
Chemical Name: AG 7352 Hydrochloride
Synonyms: SNS-595 Hydrochloride;AG 7352 Hydrochloride;Voreloxin (SNS-595) HCl;Vosaroxin Hydrochloride;Voreloxin (Hydrochloride);Vosaroxin hydrochloride salt;Voreloxin 13C-D3 Hydrochloride;Voreloxin(SNS-595)hydrochloride;Vosaroxin hydrochloride >=98% (HPLC);Voreloxin Impurity 1 (Hydrochloride)
CBNumber: CB52645152
Molecular Formula: C18H20ClN5O4S
Formula Weight: 437.9
MOL File: 175519-16-1.mol

Less

AG 7352 Hydrochloride Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: White to gray
optical activity: [α]/D +42 to +52°, c =1 in 0.1 M NaOH
Water Solubility: H2O: 1mg/mL, clear (warmed)

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0927
Product name: VoreloxinHydrochloride
Purity: 99.96%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0927
Product name: VoreloxinHydrochloride
Purity: 99.96%
Packaging: 10mg
Price: $210
Updated: 2021/12/16

ApexBio Technology

Product number: A3925
Product name: VoreloxinHydrochloride
Packaging: 5mg
Price: $221
Updated: 2021/12/16

ApexBio Technology

Product number: A3925
Product name: VoreloxinHydrochloride
Packaging: 10mg
Price: $378
Updated: 2021/12/16

ChemScene

Product number: CS-0927
Product name: VoreloxinHydrochloride
Purity: 99.96%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

Less

AG 7352 Hydrochloride Chemical Properties,Usage,Production

Uses

Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

Biological Activity

Voreloxin hydrochloride (SNS-595, Vosaroxin) is a potent Topoisomerase II inhibitor with broad-spectrum antitumor activity. Phase 2.

in vivo

Voreloxin (20 mg/kg, i.v.) alone results in 80% reduction in bone marrow cellularity of CD-1 mice by administration one dose every 4 days repeated twice (q4d ×2). voreloxin at 10 mg/kg in combination with cytarabine causes ablation of the marrow, dilation of sinusoids, and infiltration of adipocytes in mice. Voreloxin (20 mg/kg, i.v.) combined with cytarabine causes a reversible decrease in myeloid and lymphoid cells in bone marrow and peripheral blood CD-1 mice. voreloxin (10 mg/kg, q4d ×2) and cytarabine in combination causes reversible neutropenia with a more modest impact on platelets CD-1 mice^[2].

target

Target	Value
Topo II

IC 50

Topoisomerase II

References

[1] Hotinski AK, et al. Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia. Expert Opin Pharmacother. 2015 Jun;16(9):1395-402. DOI:10.1517/14656566.2015.1044437
[2] Scatena CD, et al. Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8. DOI:10.1007/s00280-009-1234-z
[3] Walsby EJ, et al. The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine. Haematologica. 2011 Mar;96(3):393-9. DOI:10.3324/haematol.2010.032680

AG 7352 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

AG 7352 Hydrochloride Suppliers

China 68 India 1 United States 8 Global 77

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7924
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9778
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Nantong Feiyu Biological Technology CO.,LTD

Tel: 0513-68819626; 15152877458
Fax: 0513-68669626
Email: feiyubio@163.com
Country: China
ProdList: 4817
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18921922613
Email: hywu@aikonchem.com
Country: China
ProdList: 10709
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 14580
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Guangzhou Tosun Pharmaceutical Limited

Tel: +86-18124244216 +86-18124244216
Email: info@upharm.cn
Country: China
ProdList: 998
Advantage: 58

Shenzhen Science Biology Co., Ltd.

Tel: 18617181553
Country: CHINA
ProdList: 112
Advantage: 58

Guangzhou Kati Biotechnology Co., Ltd.

Tel: 13128698830
Country: CHINA
ProdList: 199
Advantage: 58

Guangzhou Yanna Biotechnology Co., Ltd.

Tel: 15994750751
Country: CHINA
ProdList: 172
Advantage: 58

Guangzhou Dezi Biotechnology Co., Ltd.

Tel: 13580337740
Country: CHINA
ProdList: 129
Advantage: 58

Chongqing Haoyu Biotechnology Co., Ltd.

Tel: 18983828904
Country: CHINA
ProdList: 114
Advantage: 58

Sperui Technology (Guangzhou) Co., Ltd.

Tel: 18826050589
Country: CHINA
ProdList: 186
Advantage: 58

Guangzhou Haotian Biotechnology Co., Ltd.

Tel: 15571990006
Country: CHINA
ProdList: 122
Advantage: 58

Guangzhou Yansai Biological Products Co., Ltd.

Tel: 13710209565
Country: CHINA
ProdList: 122
Advantage: 58

Guangzhou Yiran Biotechnology Co., Ltd.

Tel: 15571990006
Country: CHINA
ProdList: 141
Advantage: 58

175519-16-1, AG 7352 HydrochlorideRelated Search:

AG 7352 Hydrochloride

SNS-595 Hydrochloride

Voreloxin (Hydrochloride)

Vosaroxin Hydrochloride

(3S-trans)-1,4-Dihydro-7-[3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid monohydrochloride

Voreloxin (SNS-595) HCl

SNS-595 HYDROCHLORIDE; VOSAROXIN HYDROCHLORIDE; AG 7352 HYDROCHLORIDE

Voreloxin(SNS-595)hydrochloride

1,8-Naphthyridine-3-carboxylic Acid, 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-, monohydrochloride

Vosaroxin hydrochloride >=98% (HPLC)

Vosaroxin hydrochloride salt

Voreloxin 13C-D3 Hydrochloride

AG 7352,Apoptosis,AG7352,Inhibitor,SNS595,inhibit,AG-7352,Voreloxin hydrochloride,SNS-595,Voreloxin,SNS 595,Topoisomerase

VoreloxinHydrochloride/AG-7352Hydrochloride

Voreloxin Impurity 1 (Hydrochloride)

7-((3S,4S)-3-Methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid hydrochloride , Voreloxin HCl

7-((3S,4S)-3-Methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid hydrochloride

Voreloxin hydrochloride, 10 mM in DMSO

Voreloxin (SNS-595) hydrochloride ，S7518

175519-16-1

C18H20ClN5O4S

C18H19N5O4SHCl