[3-(benzyloxy)-1,2-oxazol-5-yl]Methanol

Product Name: [3-(benzyloxy)-1,2-oxazol-5-yl]Methanol
CAS No.: 123320-44-5
Chemical Name: [3-(benzyloxy)-1,2-oxazol-5-yl]Methanol
Synonyms: (3-(Benzyloxy)isoxazol-5-yl)Methanol;EOS-61969;3-(Phenylmethoxy)-5-isoxazolemethanol;[3-(benzyloxy)-1,2-oxazol-5-yl]Methano;5-Isoxazolemethanol, 3-(phenylmethoxy)-;[3-(benzyloxy)-1,2-oxazol-5-yl]Methanol;(3-phenylmethoxy-1,2-oxazol-5-yl)methanol
CBNumber: CB52645637
Molecular Formula: C11H11NO3
Formula Weight: 205.21
MOL File: 123320-44-5.mol

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[3-(benzyloxy)-1,2-oxazol-5-yl]Methanol Property

Boiling point:: 396.6±32.0 °C(Predicted)
Density: 1.251±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 13.12±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0389048
Product name: (3-(BENZYLOXY)ISOXAZOL-5-YL)METHANOL
Purity: 95.00%
Packaging: 5MG
Price: $505
Updated: 2021/12/16

AK Scientific

Product number: 4459AA
Product name: (3-(Benzyloxy)isoxazol-5-yl)methanol
Packaging: 1g
Price: $516
Updated: 2021/12/16

Matrix Scientific

Product number: 126204
Product name: (3-(Benzyloxy)isoxazol-5-yl)methanol
Purity: >95%
Packaging: 1g
Price: $864
Updated: 2021/12/16

Chemenu

Product number: CM129869
Product name: (3-(benzyloxy)isoxazol-5-yl)methanol
Purity: 95+%
Packaging: 1g
Price: $327
Updated: 2021/12/16

Crysdot

Product number: CD11320343
Product name: (3-(Benzyloxy)isoxazol-5-yl)methanol
Purity: 98%
Packaging: 1g
Price: $347
Updated: 2021/12/16

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[3-(benzyloxy)-1,2-oxazol-5-yl]Methanol Chemical Properties,Usage,Production

Uses

(3-(Benzyloxy)isoxazol-5-yl)methanol is a key precursor to tetracycline antibiotics.

Synthesis

205115-22-6

123320-44-5

General procedure for the synthesis of (3-(benzyloxy)isoxazol-5-yl)methanol from methyl 3-(benzyloxy)isoxazole-5-carboxylate: to a solution of methyl 3-(benzyloxy)isoxazole-5-carboxylate (2.33 g, 9.99 mmol, 1.00 eq.) in methanol (50 mL) was added sodium borohydride (756 mg, 19.98 mmol, 2.00 equivalent). The reaction mixture was stirred at 15 °C for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether:ethyl acetate = 5:1) to confirm the completion of the reaction. The reaction mixture was slowly poured into 0.2 M hydrochloric acid solution (200 mL) and extracted with ethyl acetate (150 mL x 2). The organic phases were combined, washed with saturated saline (200 mL × 2), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give (3-(benzyloxy)isoxazol-5-yl)methanol (1.85 g, 9.02 mmol, 90% yield) as a colorless oil.LC-MS (ESI) m/z: 206.1 [M+H]+.

References

[1] Patent: WO2018/140809, 2018, A1. Location in patent: Paragraph 00443; 00551; 00554; 00555
[2] European Journal of Organic Chemistry, 1998, # 3, p. 473 - 479
[3] Patent: WO2012/87833, 2012, A1. Location in patent: Page/Page column 133
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9133 - 9153
[5] Patent: WO2008/127361, 2008, A2. Location in patent: Page/Page column 89

[3-(benzyloxy)-1,2-oxazol-5-yl]Methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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[3-(benzyloxy)-1,2-oxazol-5-yl]Methanol Suppliers

China 41 India 1 United States 3 Global 45

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123320-44-5, [3-(benzyloxy)-1,2-oxazol-5-yl]MethanolRelated Search:

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[3-(benzyloxy)-1,2-oxazol-5-yl]Methanol

(3-(Benzyloxy)isoxazol-5-yl)Methanol

[3-(benzyloxy)-1,2-oxazol-5-yl]Methano

3-(Phenylmethoxy)-5-isoxazolemethanol

123320-44-5