ChemicalBook > CAS DataBase List > ELQ－300

ELQ－300

Product Name
ELQ－300
CAS No.
1354745-52-0
Chemical Name
ELQ－300
Synonyms
ELQ－300;ELQ-300, 10 mM in DMSO;ELQ300; ELQ-300; ELQ 300;6-chloro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1H-quinolin-4-one;6-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one;4(1H)-Quinolinone, 6-chloro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-;Parasite,inhibit,ELQ 300,ELQ-300,ELQ300,acute,antimalarial,recrudescence,oral,Inhibitor,mice,infection
CBNumber
CB52648128
Molecular Formula
C24H17ClF3NO4
Formula Weight
475.84
MOL File
1354745-52-0.mol
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ELQ－300 Property

Boiling point:
551.2±50.0 °C(Predicted)
Density 
1.362±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 15.62 mg/mL (32.83 mM); Water: < 0.1 mg/mL (insoluble)
form 
Solid
pka
0.88±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0007966
Product name
ELQ-300
Purity
98.59%
Packaging
5mg
Price
$350
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0009852
Product name
ELQ-300
Purity
95.00%
Packaging
5MG
Price
$497.59
Updated
2021/12/16
ChemScene
Product number
CS-0007966
Product name
ELQ-300
Purity
98.59%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0007966
Product name
ELQ-300
Purity
98.59%
Packaging
25mg
Price
$990
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573427
Product name
ELQ300
Packaging
100mg
Price
$1060.8
Updated
2021/12/16
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ELQ－300 Chemical Properties,Usage,Production

Uses

ELQ-300 is a potent and orally bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1). ELQ-300 inhibits growth of P. falciparum Dd2, Tm90-C2B, and D1 with IC50 values of 6.6, 4.6 and 160 nM, respectively. ELQ-300 can be used for the research of antimalarial[1][2].

in vivo

ELQ-300 (1 and 10 mg/kg; p.o. once daily for 1 or 4 days) inhibits P. yoelii growth in an acute infection model[2]. ELQ-300 (10 and 20 mg/kg; p.o. once daily for 1 or 4 days) prevents recurrence of infection in mice[2].

Animal Model:6-week female CF-1 mice with P. yoelii-WT infection[2]
Dosage:1 and 10 mg/kg
Administration:Oral gavage; 1 mg/kg once daily for 4-day; 10 mg/kg once daily for 1-day
Result:Inhibited P. yoelii with ED50 values of 0.04 and 0.03 mg/kg for 4-day dosing and 1-day dosing, respectively.
Animal Model:6-week female CF-1 mice with P. yoelii-WT infection[2]
Dosage:10 and 20 mg/kg
Administration:Oral gavage; 10 mg/kg once daily for 4-day; 20 mg/kg once daily for 1-day
Result:Effectively prevented recrudescence in the 4-day dosing studies with infection mice.

References

[1] Stickles AM, et al. Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum. Antimicrob Agents Chemother. 2015 Apr;59(4):1977-82. DOI:10.1128/AAC.04149-14
[2] Stickles AM, et al. Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4853-9. DOI:10.1128/AAC.00791-16

ELQ－300 Preparation Products And Raw materials

Raw materials

Preparation Products

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ELQ－300 Suppliers

China 44 United States 5 Global 49
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
88915
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
8556
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9550
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58

1354745-52-0, ELQ－300Related Search:


  • ELQ－300
  • 6-chloro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1H-quinolin-4-one
  • ELQ300; ELQ-300; ELQ 300
  • 4(1H)-Quinolinone, 6-chloro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-
  • 6-Chloro-7-methoxy-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one
  • Parasite,inhibit,ELQ 300,ELQ-300,ELQ300,acute,antimalarial,recrudescence,oral,Inhibitor,mice,infection
  • ELQ-300, 10 mM in DMSO
  • 1354745-52-0