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11-Piperazinyldibenzo[b,e][1,4]diazepine

Product Name
11-Piperazinyldibenzo[b,e][1,4]diazepine
CAS No.
56296-18-5
Chemical Name
11-Piperazinyldibenzo[b,e][1,4]diazepine
Synonyms
DREADD agonist 1;DREADD Agonist 21;11-Piperazinyldibenzo[b,e][1,4]diazepine;11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)-;Muscarinic acetylcholine receptor,schizophrenia,mAChR,Inhibitor,muscarinic,disease,inhibit,DREADD agonist21,neurodegenerative,acetylcholine,DREADD agonist 21,DREADD,neuronal,hM3Dq,DREADD agonist-21,activation,receptors
CBNumber
CB52650796
Molecular Formula
C17H18N4
Formula Weight
278.35
MOL File
56296-18-5.mol
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11-Piperazinyldibenzo[b,e][1,4]diazepine Property

Boiling point:
470.1±55.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.8(Max Conc. mM)
Ethanol:29.61(Max Conc. mg/mL);106.39(Max Conc. mM)
form 
A crystalline solid
pka
8.56±0.10(Predicted)
color 
Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18907
Product name
DREADD Agonist 21
Purity
≥98%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
18907
Product name
DREADD Agonist 21
Purity
≥98%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
18907
Product name
DREADD Agonist 21
Purity
≥98%
Packaging
10mg
Price
$210
Updated
2024/03/01
Tocris
Product number
5548
Product name
DREADDagonist21
Purity
≥98%(HPLC)
Packaging
10
Price
$203
Updated
2021/12/16
Tocris
Product number
5548
Product name
DREADDagonist21
Purity
≥98%(HPLC)
Packaging
50
Price
$852
Updated
2021/12/16
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11-Piperazinyldibenzo[b,e][1,4]diazepine Chemical Properties,Usage,Production

Description

DREADD agonist 21 activates hM3Dq (EC50 = 1.7 nM), a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor. It does not agonize the hM3 receptor and displays relatively weaker binding affinities for serotonin 5-HT2A, 5-HT2C, α1A-adrenergic, and histamine H1 receptors (Kis = 66, 170, 280, and 6 nM, respectively).

Uses

DREADD agonist 21 is an agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD). It preferentially binds hM3Dq?DREADDs over endogenous hM3?receptors.

storage

Room temperature

11-Piperazinyldibenzo[b,e][1,4]diazepine Preparation Products And Raw materials

Raw materials

Preparation Products

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11-Piperazinyldibenzo[b,e][1,4]diazepine Suppliers

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56296-18-5, 11-Piperazinyldibenzo[b,e][1,4]diazepineRelated Search:


  • 11-Piperazinyldibenzo[b,e][1,4]diazepine
  • DREADD Agonist 21
  • 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
  • DREADD agonist 1
  • 5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)-
  • Muscarinic acetylcholine receptor,schizophrenia,mAChR,Inhibitor,muscarinic,disease,inhibit,DREADD agonist21,neurodegenerative,acetylcholine,DREADD agonist 21,DREADD,neuronal,hM3Dq,DREADD agonist-21,activation,receptors
  • 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
  • 56296-18-5