ChemicalBook > CAS DataBase List > N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)

Product Name: N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)
CAS No.: 1374744-69-0
Chemical Name: N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)
Synonyms: CL121;TG101348(2ClH.H2O);Fedratinib HCl hydrate;Fedratinib Hydrochloride;Fedratinibdihydrochloride;TG-101348 hydrochloride hydrate;Fedratinib HCl hydrate，TG101348;Fedratinib hydrochloride hydrate;SAR 302503 hydrochloride hydrate;TG-101348 dihydrochloride hydrate
CBNumber: CB52651162
Molecular Formula: C27H40Cl2N6O4S
Formula Weight: 615.6153
MOL File: 1374744-69-0.mol

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N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1) Property

solubility: DMSO:250.0(Max Conc. mg/mL);409.09(Max Conc. mM)
form: Solid
color: White to yellow
InChIKey: QAFZLTVOFJHYDF-UHFFFAOYSA-N
SMILES: C1(S(NC(C)(C)C)(=O)=O)=CC=CC(NC2C(C)=CN=C(NC3=CC=C(OCCN4CCCC4)C=C3)N=2)=C1.[H]O[H].[H]Cl.[H]Cl

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0028556
Product name: Fedratinibhydrochloridehydrate
Purity: 99.82%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0028556
Product name: Fedratinibhydrochloridehydrate
Purity: 99.82%
Packaging: 10mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-0028556
Product name: Fedratinibhydrochloridehydrate
Purity: 99.82%
Packaging: 100mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0028556
Product name: Fedratinibhydrochloridehydrate
Purity: 99.82%
Packaging: 200mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0028556
Product name: Fedratinibhydrochloridehydrate
Purity: 99.82%
Packaging: 500mg
Price: $550
Updated: 2021/12/16

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N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1) Chemical Properties,Usage,Production

Uses

A potent, highly selective and ATP-competitive JAK2 inhibitor with an IC50 of 3 nM for JAK2 and JAK2V617F.

in vivo

Fedratinib (TG101348; 60-120 mg/kg; oral gavage; twice daily; for 42 days; C57Bl/6 mice) trewatment shows a dose-dependent reduction in polycythemia and a marked dose-dependent reduction in splenomegaly of treated animals^[1].

Animal Model:	C57Bl/6 mice induced by the JAK2V617F mutation^[1]
Dosage:	60 mg/kg, 120 mg/kg
Administration:	Oral gavage; twice daily; for 42 days
Result:	Showed a statistically significant reduction in hematocrit and leukocyte count, a dose-dependent reduction/elimination of extramedullary hematopoiesis.

IC 50

JAK2: 3 nM (IC₅₀); JAK2(V617F): 3 nM (IC₅₀); Flt3: 15 nM (IC₅₀); Ret: 48 nM (IC₅₀)

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1) Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1) Suppliers

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1374744-69-0, N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)Related Search:

CL121

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)

TG101348(2ClH.H2O)

TG-101348 dihydrochloride hydrate

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate

Fedratinib hydrochloride hydrate

N-(tert-Butyl)-3-((5-methyl-2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide dihydrochloride hydrate

Fedratinib (TG101348) dihydrochloride hydrate

SAR 302503 hydrochloride hydrate

TG-101348 hydrochloride hydrate

Fedratinib Hydrochloride

Fedratinib HCl hydrate，TG101348

Fedratinib dihydrochloride monohydrate

Fedratinibdihydrochloride

STAT5,JAK2V617F,myeloproliferative,TG-101348 hydrochloride,Janus kinase,phosphorylation,anti-proliferation,FLT3,Apoptosis,inhibit,RET,orally,JAK,SAR 302503 hydrochloride,Fedratinib hydrochloride hydrate,anti-cancer,JAK2,Inhibitor,Fedratinib hydrochloride

Fedratinib HCl hydrate

Fedratinib hydrochloride hydrate, 10 mM in DMSO

1374744-69-0

C27H36N6O3S2HClH2O