Ethyl 5-broMo-1H-indole-7-carboxylate
- Product Name
- Ethyl 5-broMo-1H-indole-7-carboxylate
- CAS No.
- 1065181-58-9
- Chemical Name
- Ethyl 5-broMo-1H-indole-7-carboxylate
- Synonyms
- Ethyl 5-broMo-1H-indole-7-carboxylate;1H-Indole-7-carboxylic acid, 5-bromo-, ethyl ester
- CBNumber
- CB52651607
- Molecular Formula
- C11H10BrNO2
- Formula Weight
- 268.11
- MOL File
- 1065181-58-9.mol
Ethyl 5-broMo-1H-indole-7-carboxylate Property
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- HCH0368917
- Product name
- ETHYL-5-BROMO-1H-INDOLE-7-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.97
- Updated
- 2021/12/16
- Product number
- Z3853
- Product name
- Ethyl5-bromo-1H-indole-7-carboxylate
- Packaging
- 10g
- Price
- $1069
- Updated
- 2021/12/16
- Product number
- 126118
- Product name
- Ethyl5-bromo-1H-indole-7-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $1530
- Updated
- 2021/12/16
- Product number
- A103476
- Product name
- Ethyl5-bromo-1H-indole-7-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- A103476
- Product name
- Ethyl5-bromo-1H-indole-7-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
Ethyl 5-broMo-1H-indole-7-carboxylate Chemical Properties,Usage,Production
Synthesis
1065181-56-7
1065181-58-9
Intermediate 4: Synthesis of ethyl 5-bromo-1H-indole-7-carboxylate. Ethyl 2,3-dihydro-5-bromo-1H-indole-7-carboxylate (129.1 g, 0.48 mmol) was dissolved in chloroform (1500 mL) and DDQ (119.3 g, 525.7 mmol) was added in batches. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was filtered and the solids were washed with chloroform (3 x 500 mL). The combined filtrates were washed sequentially with 5% sodium hydroxide solution (3 x 500 mL), water (500 mL), and saturated brine (500 mL) and then dried with anhydrous sodium sulfate. The filtrate was concentrated under reduced pressure and the residue was recrystallized from ethanol to give ethyl 5-bromo-1H-indole-7-carboxylate (88 g, 69% yield). The product was analyzed by LC/MS: m/z 267.6 (M+H), retention time 1.14 min.
References
[1] Patent: WO2008/118724, 2008, A1. Location in patent: Page/Page column 66-67
[2] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 12, p. 1164 - 1169
Ethyl 5-broMo-1H-indole-7-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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