3',4'-DiMethoxy-α-naphthoflavone

Product Name: 3',4'-DiMethoxy-α-naphthoflavone
CAS No.: 14756-24-2
Chemical Name: 3',4'-DiMethoxy-α-naphthoflavone
Synonyms: DiMNF;NSC 123391;3',4'-DiMethoxy-α-naphthoflavone;3',4'-DiMethoxy-α-naphthoflavone;2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one;2-(3,4-Dimethoxyphenyl)-4H-benzo[h]chromen-4-one;2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one;4H-Naphtho[1,2-b]pyran-4-one, 2-(3,4-dimethoxyphenyl)-
CBNumber: CB52653883
Molecular Formula: C21H16O4
Formula Weight: 332.35
MOL File: 14756-24-2.mol

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3',4'-DiMethoxy-α-naphthoflavone Property

storage temp.: 2-8°C
solubility: DMSO: ≥13mg/mL
form: powder
color: white to tan
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0079
Product name: DiMNF
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $206
Updated: 2022/05/15

Usbiological

Product number: 255150
Product name: DiMNF
Packaging: 10mg
Price: $432
Updated: 2021/12/16

TRC

Product number: D461070
Product name: 3'',4''-Dimethoxy-α-naphthoflavone
Packaging: 25mg
Price: $835
Updated: 2021/12/16

Axon Medchem

Product number: Axon1935
Product name: DiMNF
Purity: 99%
Packaging: 10mg
Price: $115.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0002670
Product name: 2-(3,4-DIMETHOXYPHENYL)BENZO[H]CHROMEN-4-ONE
Purity: 95.00%
Packaging: 10MG
Price: $260.4
Updated: 2021/12/16

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3',4'-DiMethoxy-α-naphthoflavone Chemical Properties,Usage,Production

Description

DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1?DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2?Represses estrogen-inducible transcription.3

Uses

3',4'-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation.

Uses

3'',4''-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation.

References

1) Murray?et al. (2011),?Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone;? Mol. Pharmacol.,?79?508 2) Narayanan?et al. (2012),?Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure;? J. Pharmacol. Exp. Ther.,?342?345 3) Labrecque?et al. (2012),?Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines;? PLoS One,?7(1)?e29545

3',4'-DiMethoxy-α-naphthoflavone Preparation Products And Raw materials

Raw materials

Preparation Products

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3',4'-DiMethoxy-α-naphthoflavone Suppliers

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3',4'-DiMethoxy-α-naphthoflavone

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3',4'-DiMethoxy-α-naphthoflavone

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14756-24-2

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Pharmaceuticals

Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals