3',4'-DiMethoxy-α-naphthoflavone

Product Name: 3',4'-DiMethoxy-α-naphthoflavone
CAS No.: 14756-24-2
Chemical Name: 3',4'-DiMethoxy-α-naphthoflavone
Synonyms: DiMNF;NSC 123391;3',4'-DiMethoxy-α-naphthoflavone;2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one;2-(3,4-Dimethoxyphenyl)-4H-benzo[h]chromen-4-one;2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one;4H-Naphtho[1,2-b]pyran-4-one, 2-(3,4-dimethoxyphenyl)-
CBNumber: CB52653883
Molecular Formula: C21H16O4
Formula Weight: 332.35
MOL File: 14756-24-2.mol

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3',4'-DiMethoxy-α-naphthoflavone Property

storage temp.: 2-8°C
solubility: DMSO: ≥13mg/mL
form: powder
color: white to tan
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0079
Product name: DiMNF
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $206
Updated: 2022/05/15

Usbiological

Product number: 255150
Product name: DiMNF
Packaging: 10mg
Price: $432
Updated: 2021/12/16

TRC

Product number: D461070
Product name: 3'',4''-Dimethoxy-α-naphthoflavone
Packaging: 25mg
Price: $835
Updated: 2021/12/16

Axon Medchem

Product number: Axon1935
Product name: DiMNF
Purity: 99%
Packaging: 10mg
Price: $115.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0002670
Product name: 2-(3,4-DIMETHOXYPHENYL)BENZO[H]CHROMEN-4-ONE
Purity: 95.00%
Packaging: 10MG
Price: $260.4
Updated: 2021/12/16

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3',4'-DiMethoxy-α-naphthoflavone Chemical Properties,Usage,Production

Description

DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1?DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2?Represses estrogen-inducible transcription.3

Uses

3',4'-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation.

Uses

3'',4''-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation.

References

[1] IAIN A MURRAY. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone.[J]. Molecular Pharmacology, 2011, 79 3: 508-519. DOI:10.1124/mol.110.069369
[2] GITANJALI A NARAYANAN. Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure.[J]. Journal of Pharmacology and Experimental Therapeutics, 2012, 342 2: 345-355. DOI:10.1124/jpet.112.193482
[3] MARK P LABRECQUE. Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines.[J]. PLoS ONE, 2012: e29545. DOI:10.1371/journal.pone.0029545

3',4'-DiMethoxy-α-naphthoflavone Preparation Products And Raw materials

Raw materials

Preparation Products

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3',4'-DiMethoxy-α-naphthoflavone Suppliers

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3',4'-DiMethoxy-α-naphthoflavone

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Pharmaceuticals

Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals