3',4'-DiMethoxy-α-naphthoflavone
- Product Name
- 3',4'-DiMethoxy-α-naphthoflavone
- CAS No.
- 14756-24-2
- Chemical Name
- 3',4'-DiMethoxy-α-naphthoflavone
- Synonyms
- DiMNF;NSC 123391;3',4'-DiMethoxy-α-naphthoflavone;3',4'-DiMethoxy-α-naphthoflavone;2-(3,4-Dimethoxyphenyl)-benzo[h]chromen-4-one;2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one;4H-Naphtho[1,2-b]pyran-4-one, 2-(3,4-dimethoxyphenyl)-
- CBNumber
- CB52653883
- Molecular Formula
- C21H16O4
- Formula Weight
- 332.35
- MOL File
- 14756-24-2.mol
3',4'-DiMethoxy-α-naphthoflavone Property
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥13mg/mL
- form
- powder
- color
- white to tan
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
N-Bromosuccinimide Price
- Product number
- SML0079
- Product name
- DiMNF
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $206
- Updated
- 2022/05/15
- Product number
- 255150
- Product name
- DiMNF
- Packaging
- 10mg
- Price
- $432
- Updated
- 2021/12/16
- Product number
- D461070
- Product name
- 3'',4''-Dimethoxy-α-naphthoflavone
- Packaging
- 25mg
- Price
- $835
- Updated
- 2021/12/16
- Product number
- Axon1935
- Product name
- DiMNF
- Purity
- 99%
- Packaging
- 10mg
- Price
- $115.5
- Updated
- 2021/12/16
- Product number
- Axon1935
- Product name
- DiMNF
- Purity
- 99%
- Packaging
- 2x50mg
- Price
- $594
- Updated
- 2021/12/16
3',4'-DiMethoxy-α-naphthoflavone Chemical Properties,Usage,Production
Description
DiMNF (14756-24-2) is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression.1?DiMNF represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation.2?Represses estrogen-inducible transcription.3
Uses
3',4'-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation.
Uses
3'',4''-Dimethoxy-α-naphthoflavone (DiMNF) is a potent and selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Studies show that DiMNF suppresseses cytokine-mediated complement factor gene expression through selective activation of the Ah receptor. DiMNF has therapeutic potential in regulating the immune response to tumor formation.
References
1) Murray?et al. (2011),?Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3’,4’-dimethoxy-α-naphthoflavone;? Mol. Pharmacol.,?79?508 2) Narayanan?et al. (2012),?Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure;? J. Pharmacol. Exp. Ther.,?342?345 3) Labrecque?et al. (2012),?Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines;? PLoS One,?7(1)?e29545