EI1

Product Name: EI1
CAS No.: 1418308-27-6
Chemical Name: EI1
Synonyms: EI1;CS-2378;EI1;EI 1;KB-145943;EI1 USP/EP/BP;EI1;EI-1;EI 1;EI1 (KB145943;Ezh2 inhibitor;EI1 (Ezh2 inhibitor;Histone Methyltransferase,Inhibitor,inhibit,Apoptosis,EI-1,EI1,KB145943,EI 1,KB 145943
CBNumber: CB52655403
Molecular Formula: C23H26N4O2
Formula Weight: 390.48
MOL File: 1418308-27-6.mol

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EI1 Property

Boiling point:: 675.9±55.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥19.5 mg/mL in DMSO
form: Powder
pka: 11.88±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.00561
Product name: Ezh2 Inhibitor II, EI1 - CAS 1418308-27-6 - Calbiochem
Packaging: 10mg
Price: $265
Updated: 2024/03/01

Cayman Chemical

Product number: 19146
Product name: EI1
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19146
Product name: EI1
Purity: ≥98%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 19146
Product name: EI1
Purity: ≥98%
Packaging: 10mg
Price: $213
Updated: 2024/03/01

ChemScene

Product number: CS-1654
Product name: EI1
Purity: 99.18%
Packaging: 5mg
Price: $95
Updated: 2021/12/16

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EI1 Chemical Properties,Usage,Production

Description

EZH2 is a histone methyltransferase and its activation leads to alteration in cell cycle regulation, proliferation, and cancer progression [65]. High expression and mutation of EZH2 are in a variety of malignancies and usually portend for a poor prognosis.

Pharmacology

EZH2 has been shown to repress the cell cycle inhibitor p21 and other proapoptotic factors, thereby promoting cell cycling in SCLC cells. In various SCLC cell lines, suppression of EZH2 leads to reduction of cells in S, G2/M phase with increased p21 expression. EZH2 was also shown to prevent apoptosis by inhibition of TGF-β via histone methyltransferase methylation of lysine 27?in histone H3 (H3K27me3). In addition, it has been shown that in platinum-resistant cancer cells, protein and mRNA expression EZH2 is upregulated and by silencing EZH2 overcomes drug resistance, making EZH2 a target of interest in SCLC.

in vitro

based on studies from dlbcl cells, it was shown that ei1 suppressed cellular h3k27 methylation and activated expression of ezh2 target gene - p16. ei1 also blocked h3k27 methylation and cell proliferation in mouse embryonic fibroblasts. in addition, ei1 potently and selectively inhibited the growth of dlbcl cells carrying ezh2 mutation, and therefore resulted in cell cycle arrest and apoptosis. [1]

IC 50

a potent and selective suppressor of ezh2 with ic50 values of 15 nm and 13 nm for wild type ezh2 and ezh2 y641f mutant, respectively

References

[1]qia w, chan hm, teng l, li l, chuai s, zhang rp, zeng j, li m, fan h, lin y, gu j, ardayfiob o, zhang jh, yan x, fang j, mi y, zhang m, zhou t, feng g, chen zj, li g, yang t, zhao k, liu x, yu z, lu cx, atadja p and li e. selective inhibition of ezh2 by a small molecule inhibitor blocks tumor cells proliferation. proc natl acad sci. 2012 dec; 109(52): 213605.

EI1 Preparation Products And Raw materials

Raw materials

Preparation Products

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EI1 Suppliers

China 62 India 1 United States 10 Global 73

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

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Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

ApexBio Technology

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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

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Country: United States
ProdList: 6213
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MedChemExpress

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Country: United States
ProdList: 6398
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View Lastest Price from EI1 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: EI1 1418308-27-6
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

1418308-27-6, EI1Related Search:

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EI1

Ezh2 inhibitor

CS-2378

EI1 (Ezh2 inhibitor

EI1;EI 1

6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide

EI1;EI-1;EI 1

6-cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide

KB-145943

1H-Indole-4-carboxamide, 6-cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-

EI1 USP/EP/BP

EI1 (KB145943

Histone Methyltransferase,Inhibitor,inhibit,Apoptosis,EI-1,EI1,KB145943,EI 1,KB 145943

1418308-27-6

Inhibitors

API