1H-Indazole, 6-broMo-5-chloro-
Uses- Product Name
- 1H-Indazole, 6-broMo-5-chloro-
- CAS No.
- 1305208-02-9
- Chemical Name
- 1H-Indazole, 6-broMo-5-chloro-
- Synonyms
- 6-Bromo-5-chloro-2H-indazole;6-bromo-5-chloro-1H-indazole;1H-Indazole, 6-broMo-5-chloro-
- CBNumber
- CB52658116
- Molecular Formula
- C7H4BrClN2
- Formula Weight
- 231.48
- MOL File
- 1305208-02-9.mol
1H-Indazole, 6-broMo-5-chloro- Property
- Boiling point:
- 374.7±22.0 °C(Predicted)
- Density
- 1.878±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.59±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B702950
- Product name
- 6-Bromo-5-chloro-1H-indazole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3466AJ
- Product name
- 6-Bromo-5-chloro-1H-indazole
- Packaging
- 1g
- Price
- $331
- Updated
- 2021/12/16
- Product number
- HCH0419666
- Product name
- 6-BROMO-5-CHLORO-1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.54
- Updated
- 2021/12/16
- Product number
- 123483
- Product name
- 6-Bromo-5-chloro-1H-indazole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $775
- Updated
- 2021/12/16
- Product number
- 3H31-D-02
- Product name
- 6-Bromo-5-chloro-1H-indazole
- Packaging
- 250mg
- Price
- $909
- Updated
- 2021/12/16
1H-Indazole, 6-broMo-5-chloro- Chemical Properties,Usage,Production
Uses
6-Bromo-5-chloro-1H-indazole is a fine chemical raw material that can be used as an intermediate in organic synthesis.
Synthesis
1126367-88-1
1305208-02-9
Preparation of 6-bromo-5-chloro-1H-indazole (Compound x23): To a solution of 5-bromo-4-chloro-2-methylaniline (1 g, 4.54 mmol) in acetic acid (10 mL) was slowly added dropwise a solution of sodium nitrite (0.329 g, 4.76 mmol) in water (1 mL). The reaction mixture was heated to reflux and maintained for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove most of the solvent. The concentrated residue was dispersed in water and extracted with ethyl acetate (EtOAc). All organic phases were combined, washed with saturated brine and subsequently dried with anhydrous magnesium sulfate. After filtration to remove the drying agent, the filtrate was concentrated under reduced pressure to afford the title compound 6-bromo-5-chloro-1H-indazole (0.67 g, 64% yield) in the form of a reddish brown solid. It was analyzed by electrospray ionization mass spectrometry (ESI-MS) and the molecular ion peak [M + H]+ was measured as 232.2.
References
[1] Patent: WO2013/148603, 2013, A1. Location in patent: Paragraph 0242-0243
[2] Patent: WO2017/12576, 2017, A1. Location in patent: Page/Page column 332; 333
[3] Patent: WO2018/137593, 2018, A1. Location in patent: Page/Page column 83
1H-Indazole, 6-broMo-5-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Indazole, 6-broMo-5-chloro- manufacturers
- Product
- 1H-Indazole, 6-broMo-5-chloro- 1305208-02-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14