2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
- Product Name
- 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
- CAS No.
- 68119-31-3
- Chemical Name
- 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
- Synonyms
- 2-(2,2-difL;Lummakato impurities2;Thiocoraline Impurity15;2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl);(2,2-Difluorobenzodioxol-5-yl)acetonitrile;2,2-Difluoro-1,3-benzodioxole-5-acetonitrile;5-(Cyanomethyl)-2,2-Difluoro-1,3-benzodioxole;1,3-Benzodioxole-5-acetonitrile, 2,2-difluoro-;(2,2-Difluoro-1,3-benzodioxol-5-yl)acetonitrile;2,2-Difluorobenzo[d][1,3]dioxole-5-acetonitrile
- CBNumber
- CB52658237
- Molecular Formula
- C9H5F2NO2
- Formula Weight
- 197.14
- MOL File
- 68119-31-3.mol
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile Property
- Boiling point:
- 249.4±40.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Pale Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D452093
- Product name
- 2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-M2546
- Product name
- 1,3-Benzodioxole-5-acetonitrile,2,2-difluoro-
- Packaging
- 10g
- Price
- $94
- Updated
- 2021/12/16
- Product number
- J95542
- Product name
- 2-(2,2-Difluorobenzo[D][1,3]dioxol-5-yl)acetonitrile
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 3087AH
- Product name
- 2-(2,2-Difluorobenzo[D][1,3]dioxol-5-yl)acetonitrile
- Packaging
- 10g
- Price
- $231
- Updated
- 2021/12/16
- Product number
- 4H37-3-28
- Product name
- 2-(2,2-Difluoro-2H-1,3-benzodioxol-5-yl)acetonitrile
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $490
- Updated
- 2021/12/16
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile Chemical Properties,Usage,Production
Synthesis
476473-97-9
68119-31-3
General procedure for the synthesis of (2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile from 5-(chloromethyl)-2,2-difluorobenzo[d][1,3]dioxol-5-yl: To a solution of 5-(chloromethyl)-2,2-difluoro-1,3-benzo[d][1,3]dioxol-5-yl (1 eq.) in DMSO (1 vol.), NaCN (1.4 eq.) in a suspension in DMSO (3 vol), keeping the reaction temperature between 30-40 °C. The reaction mixture was stirred for 1 h and then water (6 vol) and methyl tert-butyl ether (MTBE, 4 vol) were added. The organic and aqueous layers were separated and the aqueous layer was further extracted with MTBE (1.8 vol). All organic layers were combined, washed with water (1.8 v/v) and subsequently dried over anhydrous sodium sulfate, filtered and concentrated to afford the crude product (2,2-difluoro-1,3-benzodioxol-5-yl)-acetonitrile in 95% yield. The crude product did not require further purification and could be used directly in the subsequent reaction step. The subsequent steps were the same as those described above for the acid portion of the synthesis.
References
[1] Patent: US2012/15999, 2012, A1
[2] Patent: WO2016/109362, 2016, A1. Location in patent: Paragraph 00160
[3] Patent: US2011/98311, 2011, A1
[4] Patent: US2011/98311, 2011, A1
[5] Patent: US2011/98311, 2011, A1
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile manufacturers
- Product
- 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 68119-31-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-06
- Product
- 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 68119-31-3
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 68119-31-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- as request
- Release date
- 2018-12-23