Piperidine,4-(4-broMophenyl)-1-(Methylsulfonyl)-
Uses- Product Name
- Piperidine,4-(4-broMophenyl)-1-(Methylsulfonyl)-
- CAS No.
- 622386-94-1
- Chemical Name
- Piperidine,4-(4-broMophenyl)-1-(Methylsulfonyl)-
- Synonyms
- 4-(4-BROMOPHENYL)-1-(METHYLSULFONYL)PIPERIDINE;Piperidine,4-(4-broMophenyl)-1-(Methylsulfonyl)-;Piperidine,4-(4-broMophenyl)-1-(MetChemicalbookhylsulfonyl)-
- CBNumber
- CB52658343
- Molecular Formula
- C12H16BrNO2S
- Formula Weight
- 318.23
- MOL File
- 622386-94-1.mol
Piperidine,4-(4-broMophenyl)-1-(Methylsulfonyl)- Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C12H16BrNO2S/c1-17(15,16)14-8-6-11(7-9-14)10-2-4-12(13)5-3-10/h2-5,11H,6-9H2,1H3
- InChIKey
- HFRCPNHFAFLBMD-UHFFFAOYSA-N
- SMILES
- N1(S(C)(=O)=O)CCC(C2=CC=C(Br)C=C2)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 9361AB
- Product name
- 4-(4-Bromophenyl)-1-(methylsulfonyl)piperidine
- Packaging
- 10g
- Price
- $371
- Updated
- 2021/12/16
- Product number
- HCH0365213
- Product name
- 4-(4-BROMOPHENYL)-1-(METHYLSULFONYL)PIPERIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.52
- Updated
- 2021/12/16
- Product number
- A167921
- Product name
- 4-(4-Bromophenyl)-1-(methylsulfonyl)piperidine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $17
- Updated
- 2021/12/16
- Product number
- A167921
- Product name
- 4-(4-Bromophenyl)-1-(methylsulfonyl)piperidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- CD11087671
- Product name
- 4-(4-Bromophenyl)-1-(methylsulfonyl)piperidine
- Purity
- 95+%
- Packaging
- 10g
- Price
- $236
- Updated
- 2021/12/16
Piperidine,4-(4-broMophenyl)-1-(Methylsulfonyl)- Chemical Properties,Usage,Production
Uses
4-(4-bromophenyl)-1-(methylsulfonyl)piperidine is a piperidine derivative used in pharmaceutical synthesis and experimental research.
Synthesis
287954-99-8
622386-94-1
To the methanesulfonamide in Part A was added dichloromethane (300 mL) and triethylsilane (125 mL, 778 mmol). Trifluoroacetic acid (300 mL, 3.9 mol) was added to the suspension. The resulting mixture was stirred at ambient temperature for 1 hr while keeping the reaction vessel sealed, followed by vacuum concentration to give a solid product. The solid was mixed with methanol (150 mL) in a sealed flask at ambient temperature for 2 days. Afterwards, the solid was separated from the suspension by filtration and washed with additional methanol (100 mL). The resulting solid was dried in a vacuum oven at 50 °C overnight to yield 54.14 g (91.7% yield) of the target product 4-(4-bromophenyl)-1-(methylsulfonyl)piperidine. The structure of the product was confirmed by 1H NMR analysis.
References
[1] Patent: US2005/9838, 2005, A1. Location in patent: Page 135; 303; 308; 347
Piperidine,4-(4-broMophenyl)-1-(Methylsulfonyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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