2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine

Product Name: 2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine
CAS No.: 1260088-72-9
Chemical Name: 2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine
Synonyms: 2,4-dichloro-7,7-dimethyl-5H-furo[3,4-d]pyrimidine;2,4-dichloro-7,7-dimethyl-5H,7H-furo[3,4-d]pyrimidine;2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine;2,4-dichloro-5,7-dihydro-7,7-dimethylFuro[3,4-d]pyrimidine;Furo[3,4-d]pyrimidine, 2,4-dichloro-5,7-dihydro-7,7-dimethyl-
CBNumber: CB52658752
Molecular Formula: C8H8Cl2N2O
Formula Weight: 219.07
MOL File: 1260088-72-9.mol

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2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine Property

Boiling point:: 317.6±42.0 °C(Predicted)
Density: 1.383±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.37±0.40(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D438123
Product name: 2,4-Dichloro-5,7-dihydro-7,7-dimethylfuro[3,4-d]pyrimidine
Packaging: 50mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: 3281AD
Product name: 2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine
Packaging: 100mg
Price: $382
Updated: 2021/12/16

Matrix Scientific

Product number: 101633
Product name: 2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine
Purity: 99%
Packaging: 250mg
Price: $555
Updated: 2021/12/16

Matrix Scientific

Product number: 101633
Product name: 2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine
Purity: 99%
Packaging: 500mg
Price: $887
Updated: 2021/12/16

AK Scientific

Product number: 3281AD
Product name: 2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine
Packaging: 1g
Price: $1366
Updated: 2021/12/16

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2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine Chemical Properties,Usage,Production

Uses

2,4-Dichloro-5,7-dihydro-7,7-dimethylfuro[3,4-d]pyrimidine is used for preparation and study of pharmacokinetics, and antitumor activity of dihydrofuro[3,4-d]pyrimidines as inhibitors of mammalian target of rapamycin kinase.

Synthesis

1260088-71-8

1260088-72-9

Step 3 - Synthesis of 2,4-dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine (p): a mixture of 7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine-2,4(1H,3H)-dione (o) (2.55 g, 14.0 mmol), phosphinic acid chloride (15 mL, 160 mmol) and 1,2-dichloroethane ( The mixture of 80 mL) was heated at 80 °C for 20 hours. Upon completion of the reaction, the mixture was concentrated to a solid and partitioned between dichloromethane (250 mL) and saturated NaHCO3 solution (500 mL). The organic and aqueous phases were separated and the aqueous phase was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, dried over anhydrous Na2SO4, filtered and concentrated to afford 2.53 g (82% yield) of 2,4-dichloro-7,7-dimethyl-5,7-dihydrofurano[3,4-d]pyrimidine (p) as a colorless solid. Product characterization data: 1H NMR (400 MHz, CDCl3) δ 5.02 (s, 2H), 1.51 (s, 6H); LC-MS: m/z = 219(M+H)+.

References

[1] Patent: US2010/331305, 2010, A1. Location in patent: Page/Page column 32-33
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 9, p. 3426 - 3435

2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine manufacturers

Career Henan Chemical Co

Product: 2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidine 1260088-72-9
Price: US $1.00/g
Min. Order: 1g
Purity: 97%
Supply Ability: 100kg
Release date: 2020-01-09

1260088-72-9, 2,4-Dichloro-7,7-diMethyl-5,7-dihydrofuro[3,4-d]pyriMidineRelated Search:

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1260088-72-9