4-Ethoxy-1H-pyrrolo[2,3-b]pyridine

Product Name: 4-Ethoxy-1H-pyrrolo[2,3-b]pyridine
CAS No.: 1011711-57-1
Chemical Name: 4-Ethoxy-1H-pyrrolo[2,3-b]pyridine
Synonyms: 4-Ethoxy-7-azaindole;4-Ethoxy-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4-ethoxy-
CBNumber: CB52666135
Molecular Formula: C9H10N2O
Formula Weight: 162.19
MOL File: 1011711-57-1.mol

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4-Ethoxy-1H-pyrrolo[2,3-b]pyridine Property

Melting point:: 176-178 °C(Solv: ethyl ether (60-29-7))
Density: 1.196±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 14.16±0.40(Predicted)
Appearance: white to off-white solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0155993
Product name: 4-ETHOXY-1H-PYRROLO[2,3-B]PYRIDINE
Purity: 95.00%
Packaging: 1MG
Price: $628.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0155993
Product name: 4-ETHOXY-1H-PYRROLO[2,3-B]PYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $667.02
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0155993
Product name: 4-ETHOXY-1H-PYRROLO[2,3-B]PYRIDINE
Purity: 95.00%
Packaging: 10MG
Price: $675.51
Updated: 2021/12/16

AK Scientific

Product number: 0343AA
Product name: 4-Ethoxy-1H-pyrrolo[2,3-b]pyridine
Packaging: 5g
Price: $1673
Updated: 2021/12/16

Alichem

Product number: 1011711571
Product name: 4-Ethoxy-7-azaindole
Packaging: 1g
Price: $1752.4
Updated: 2021/12/16

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4-Ethoxy-1H-pyrrolo[2,3-b]pyridine Chemical Properties,Usage,Production

Synthesis

64-17-5

74420-02-3

1011711-57-1

Diethyl azodicarboxylate (DEAD) (520 μL, 3.3 mmol) was slowly added dropwise to an anhydrous tetrahydrofuran (THF) (13 mL) solution of triphenylphosphine (PPh3) (1.04 g, 3.96 mmol) at ambient temperature and under an inert atmosphere. Subsequently, the mixed solution was transferred to a round-bottomed flask containing a solution of anhydrous THF (41 mL) with 4-hydroxy-7-azaindole (222 mg, 1.65 mmol) and ethanol (115 μL, 1.98 mmol) under an inert atmosphere. The reaction mixture was stirred for 2 h at ambient temperature. After completion of the reaction, the solvent was removed by rotary evaporator. The resulting crude product was purified by column chromatography (eluent: dichloromethane/methanol, 98:2) to afford the target compound 4-ethoxy-1H-pyrrolo[2,3-b]pyridine (214 mg, 80% yield). The product was a solid with a melting point of 176-178 °C (ether); 1H NMR (300 MHz, CDCl3) δ 1.52 (t, 3H, J = 7.1 Hz, CH3), 4.26 (q, 2H, J = 7.1 Hz, CH2), 6.53 (d, 1H, J = 5.6 Hz, Harom), 6.59 (wide s, 1H, Harom) , 7.18 (broad s, 1H, Harom), 8.18 (d, 1H, J = 5.6 Hz, Harom), 9.64 (broad s, 1H, NH); mass spectrum (SI) m/z 163 (M + H+).

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 4, p. 737 - 751
[2] Patent: US2010/184790, 2010, A1. Location in patent: Page/Page column 5

4-Ethoxy-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Ethoxy-1H-pyrrolo[2,3-b]pyridine Suppliers

China 18 India 1 United States 1 Global 20

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1011711-57-1, 4-Ethoxy-1H-pyrrolo[2,3-b]pyridineRelated Search:

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4-Ethoxy-1H-pyrrolo[2,3-b]pyridine

4-Ethoxy-7-azaindole

1H-Pyrrolo[2,3-b]pyridine, 4-ethoxy-

1011711-57-1