AlviMopan (Monohydrate)

Product Name: AlviMopan (Monohydrate)
CAS No.: 1383577-62-5
Chemical Name: AlviMopan (Monohydrate)
Synonyms: AlviMopan (Monohydrate);((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycine hydrate;N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine hydrate (1:1)
CBNumber: CB52666584
Molecular Formula: C25H34N2O5
Formula Weight: 442.56
MOL File: 1383577-62-5.mol

More

Less

AlviMopan (Monohydrate) Property

storage temp.: Store at -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-1539
Product name: Alvimopan(monohydrate)
Purity: 99.18%
Packaging: 2mg
Price: $80
Updated: 2021/12/16

CSNpharm

Product number: CSN17774
Product name: AlvimopanMonohydrate
Packaging: 10mg
Price: $140
Updated: 2021/12/16

CSNpharm

Product number: CSN17774
Product name: AlvimopanMonohydrate
Packaging: 25mg
Price: $265
Updated: 2021/12/16

Crysdot

Product number: CD31003675
Product name: Alvimopanmonohydrate
Purity: 98+%
Packaging: 5mg
Price: $320
Updated: 2021/12/16

Crysdot

Product number: CD31003675
Product name: Alvimopanmonohydrate
Purity: 98+%
Packaging: 10mg
Price: $440
Updated: 2021/12/16

More

Less

AlviMopan (Monohydrate) Chemical Properties,Usage,Production

Uses

Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan monohydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan monohydrate can be used for the research of postoperative ileus[1][2][3].

in vivo

Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of ¹¹³Sn-labelled microspheres in rats^[3].
Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats^[3].

IC 50

μ Opioid Receptor/MOR

References

[1] Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12. DOI:10.1016/j.bmcl.2008.01.106
[2] Erowele GI, et, al. Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus. P T. 2008 Oct;33(10):574-83. PMID:19750041
[3] Meerveld BG, et, al. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:46-53. DOI:10.1111/j.1743-3150.2004.00555.x

AlviMopan (Monohydrate) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AlviMopan (Monohydrate) Suppliers

China 21 United States 10 Global 31

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

1383577-62-5, AlviMopan (Monohydrate)Related Search:

Alvimopan hydrate

AlviMopan (Monohydrate)

N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine hydrate (1:1)

((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycine hydrate

1383577-62-5

C25H32N2O4H2O