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BMN 673 (8R,9S)

Product Name
BMN 673 (8R,9S)
CAS No.
1207456-00-5
Chemical Name
BMN 673 (8R,9S)
Synonyms
BMN673 (8R;9S)-BMN-673;BMN 673 (8R;LT-673 8R,9S;BMN673 isomer;S-Talazoparib;BMN673 (8R,9S);(8R,9S)-LT-673;BMN-673 (8R,9S);(8R,9S)-BMN-673
CBNumber
CB52666599
Molecular Formula
C19H14F2N6O
Formula Weight
380.35
MOL File
1207456-00-5.mol
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BMN 673 (8R,9S) Property

Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥38 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥15.03 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
10.14±0.60(Predicted)
color 
White to off-white
InChI
InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m0/s1
InChIKey
HWGQMRYQVZSGDQ-HOTGVXAUSA-N
SMILES
C1(=O)C2=C3C(N[C@@H](C4=CC=C(F)C=C4)[C@H](C4N(C)N=CN=4)C3=NN1)=CC(F)=C2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A3246
Product name
BMN-6738R,9S
Packaging
10mg
Price
$257
Updated
2021/12/16
ChemScene
Product number
CS-1223
Product name
(8R,9S)-Talazoparib
Purity
95.08%
Packaging
1mg
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-1223
Product name
(8R,9S)-Talazoparib
Purity
95.08%
Packaging
5mg
Price
$350
Updated
2021/12/16
ApexBio Technology
Product number
A3246
Product name
BMN-6738R,9S
Packaging
50mg
Price
$618
Updated
2021/12/16
Matrix Scientific
Product number
120855
Product name
(8R,9S)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
Purity
97%
Packaging
50mg
Price
$1530
Updated
2021/12/16
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BMN 673 (8R,9S) Chemical Properties,Usage,Production

Uses

(8R,9S)-Talazoparib ((8R,9S)-BMN-673) is an enantiomer of Talazoparib. (8R,9S)-Talazoparib is an PARP1 inhibitor, with an IC50 of 144 nM[1].

IC 50

PARP-1: 144 nM (IC50)

References

[1] Wang B, et al. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP- DOI:10.1021/acs.jmedchem.5b01498

BMN 673 (8R,9S) Preparation Products And Raw materials

Raw materials

Preparation Products

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BMN 673 (8R,9S) Suppliers

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BOC Sciences
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View Lastest Price from BMN 673 (8R,9S) manufacturers

Career Henan Chemical Co
Product
BMN 673 (8R,9S) 1207456-00-5
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-21

1207456-00-5, BMN 673 (8R,9S)Related Search:


  • (8R,9S)-BMN-673
  • (8R,9S)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one
  • BMN 673 (8R,9S)
  • BMN673 (8R,9S)
  • BMN-673 (8R,9S)
  • (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-Methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
  • (8R,9S)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-Methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one
  • 3H-Pyrido[4,3,2-de]phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8R,9S)-
  • (8R,9S)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4
  • Talazoparib (BMN 673) 8R,9S
  • BMN-673 8R,9R isomer
  • BMN673 enantiomer
  • (8R,9S)-Talazoparib
  • (8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one
  • (8R,9S)-LT-673
  • Talazoparib 8R,9S
  • 9S)-BMN-673
  • BMN 673 (8R
  • BMN673 (8R
  • Talazoparib (8R
  • TALAZOPARIB (8R;9S);(8R;9S)-BMN-673;BMN673 (8R;9S);BMN 673 (8R;9S)
  • LT-673 8R,9S
  • BMN673 isomer
  • Talazoparib racemic
  • S-Talazoparib
  • 9S)-Talazoparib
  • rac-Carbidopa EP Impurity I (3-Bromo rac-Carbidopa)
  • STJ enantiomers
  • 1207456-00-5
  • API