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GRT6005

Product Name
GRT6005
CAS No.
863513-91-1
Chemical Name
GRT6005
Synonyms
CS-1065;GRT6005;GRT-6005;GRT 6005;Cebranopadol;Cebranopadol(GRT-6005);GRT-6005; GRT 6005; GRT6005;Cebranopadol, 10 mM in DMSO;GRT 6005,Inhibitor,Cebranopadol,inhibit,Opioid Receptor,GRT-6005;6-fluoro-N,N-dimethyl-1'-phenylspiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine
CBNumber
CB52666610
Molecular Formula
C24H27FN2O
Formula Weight
378.48
MOL File
863513-91-1.mol
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GRT6005 Property

Melting point:
>245°C (dec.)
Boiling point:
547.5±50.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly)
pka
16.79±0.40(Predicted)
form 
Solid
color 
White to Pale Yellow
InChI
InChI=1/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3/t23-,24-
InChIKey
CSMVOZKEWSOFER-RQNOJGIXNA-N
SMILES
C1C[C@]2(CC[C@]1(C1=CC=CC=C1)N(C)C)OCCC1C3C=C(F)C=CC=3NC2=1 |&1:2,5,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29500
Product name
Cebranopadol
Packaging
5mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
29500
Product name
Cebranopadol
Packaging
10mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
29500
Product name
Cebranopadol
Packaging
25mg
Price
$231
Updated
2024/03/01
TRC
Product number
C228810
Product name
Cebranopadol
Packaging
10mg
Price
$260
Updated
2021/12/16
Usbiological
Product number
444082
Product name
Cebranopadol
Packaging
5mg
Price
$460
Updated
2021/12/16
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GRT6005 Chemical Properties,Usage,Production

Uses

Cebranopadol can be obtained from 1,4-Cyclohexanedione Monoethylene Acetal (C987955) which is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal (C987955) is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

in vivo

Cebranopadol exhibits highly potent and efficacious antinociceptive and antihypersensitive effects in several rat models of acute and chronic pain (tail-flick, rheumatoid arthritis, bone cancer, spinal nerve ligation, diabetic neuropathy) with ED50 values of 0.5-5.6 μg/kg after intravenous and 25.1 μg/kg after oral administration. In comparison with selective MOP receptor agonists, cebranopadol is more potent in models of chronic neuropathic than acute nociceptive pain. Cebranopadol’s duration of action is long (up to 7 hours after intravenous 12 μg/kg; >9 hours after oral 55 μg/kg in the rat tail-flick test). The antihypersensitive activity of cebranopadol in the spinal nerve ligation model is partially reversed by pretreatment with the selective NOP receptor antagonist J-113397 or the opioid receptor antagonist naloxone, indicating that both NOP and opioid receptor agonism are involved in this activity[1].

GRT6005 Preparation Products And Raw materials

Raw materials

Preparation Products

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GRT6005 Suppliers

China 55 India 2 United States 11 Global 68
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1946
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
Country
China
ProdList
984
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
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View Lastest Price from GRT6005 manufacturers

Career Henan Chemical Co
Product
GRT6005 863513-91-1
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

863513-91-1, GRT6005Related Search:


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  • Cebranopadol, 10 mM in DMSO
  • 863513-91-1
  • C24H27FN2O